{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:39:37Z","timestamp":1791092377097,"version":"4.1.0"},"reference-count":31,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2014,11,10]],"date-time":"2014-11-10T00:00:00Z","timestamp":1415577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cardiovasc Pharmacol Ther"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Recent clinical studies have reported the potential benefit of an early mineralocorticoid receptor (MR) blockade with potassium canrenoate (PC) on ventricular arrhythmias (VAs) occurrence in patients experiencing an ST-segment elevation myocardial infarction (STEMI). However, most of the electrophysiological properties of PC demonstrated to date have been investigated in normoxic conditions, and therefore, in vitro experiments during an acute myocardial ischemia\u2013reperfusion were lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>We used rabbit in vitro models and standard microelectrode technique to assess the electrophysiological impact of PC during myocardial ischemia\u2013reperfusion, including right ventricle mimicking the \u201cborder zone\u201d existing between normal and ischemic\/reperfused areas (1 \u00b5mol\/L, 10 and 100 nmol\/L), isolated right ventricle, and sinoatrial node (SAN) experiments (1 \u00b5mol\/L, respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      During ischemia\u2013reperfusion, acute superfusion of PC 100 nmol\/L prevented the increase in action potential (AP) duration at 90% of repolarization (APD\n                      <jats:sub>90<\/jats:sub>\n                      ) dispersion between ischemic and nonischemic areas and in VAs occurrence induced by aldosterone 10 nmol\/L (86 \u00b1 3 vs 114 \u00b1 4 milliseconds for aldosterone alone, P &lt; .05). Potassium canrenoate also induced conduction blocks and significantly decreased V\n                      <jats:sub>max<\/jats:sub>\n                      during simulated ischemia (from 25 \u00b1 5 to 12 \u00b1 4, 14 \u00b1 3, and 14 \u00b1 5 V\/s, respectively, for PC 1 \u00b5mol\/L, 100, and 10 nmol\/L, P &lt; .05). Potassium canrenoate 1 \u00b5mol\/L demonstrated cycle length (CL)-dependent effects on APD\n                      <jats:sub>90<\/jats:sub>\n                      and on V\n                      <jats:sub>max<\/jats:sub>\n                      , and it also reduced SAN beating CL (from 446 \u00b1 28 to 529 \u00b1 24 millisecond, P &lt; .05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our experimental study highlights new evidence for an antiarrhythmic impact of PC during myocardial ischemia\u2013reperfusion via multiple channels modulation. These results are in line with recent clinical trials suggesting that an early MR blockade in STEMI may be preventive of VAs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1074248414557036","type":"journal-article","created":{"date-parts":[[2014,11,11]],"date-time":"2014-11-11T21:32:07Z","timestamp":1415741527000},"page":"313-321","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Electrophysiological and Antiarrhythmic Properties of Potassium Canrenoate During Myocardial Ischemia\u2013Reperfusion"],"prefix":"10.1177","volume":"20","author":[{"given":"Joachim","family":"Alexandre","sequence":"first","affiliation":[{"name":"Department of Cardiology, CHU de Caen, Caen, France"},{"name":"Universit\u00e9 de Caen Basse-Normandie, EA 4650 Signalisation, \u00e9lectrophysiologie et imagerie des l\u00e9sions d\u2019isch\u00e9mie-reperfusion myocardique, Caen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farzin","family":"Beygui","sequence":"additional","affiliation":[{"name":"Department of Cardiology, CHU de Caen, Caen, France"},{"name":"Universit\u00e9 de Caen Basse-Normandie, Medical School, Caen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo-Emilio","family":"Puddu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, Sapienza University, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Manrique","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Caen Basse-Normandie, EA 4650 Signalisation, \u00e9lectrophysiologie et imagerie des l\u00e9sions d\u2019isch\u00e9mie-reperfusion myocardique, Caen, France"},{"name":"Universit\u00e9 de Caen Basse-Normandie, Medical School, Caen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9","family":"Rouet","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Caen Basse-Normandie, EA 4650 Signalisation, \u00e9lectrophysiologie et imagerie des l\u00e9sions d\u2019isch\u00e9mie-reperfusion myocardique, Caen, France"},{"name":"Universit\u00e9 de Caen Basse-Normandie, Medical School, Caen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Milliez","sequence":"additional","affiliation":[{"name":"Department of Cardiology, CHU de Caen, Caen, France"},{"name":"Universit\u00e9 de Caen Basse-Normandie, EA 4650 Signalisation, \u00e9lectrophysiologie et imagerie des l\u00e9sions d\u2019isch\u00e9mie-reperfusion myocardique, Caen, France"},{"name":"Universit\u00e9 de Caen Basse-Normandie, Medical School, Caen, 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