{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T06:23:48Z","timestamp":1777530228524,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2015,4,20]],"date-time":"2015-04-20T00:00:00Z","timestamp":1429488000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cardiovasc Pharmacol Ther"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction and Objectives:<\/jats:title>\n                    <jats:p>Atherosclerosis is recognized as a chronic inflammatory disease. The aim of this study was to examine the role of urinary trypsin inhibitor (UTI) in inflammation response induced by hyperlipidemia in rabbits.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Thirty rabbits after injury of the right iliac artery endothelium were randomly divided into 3 groups: control group, model group, and UTI group. Iliac arteries were isolated and histology was performed on arterial regions that were injured by balloon after 8 weeks. Neointimal thickness (NT) and neointimal to media radio (N\/M) were measured. Blood lipids, interleukin 6, and tumor necrosis factor-\u03b1 were evaluated. Macrophages were evaluated by immunohistochemical analysis. MicroRNA-181b (miR-181b) was measured by reverse transcriptase-polymerase chain reaction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Urinary trypsin inhibitor therapy decreased serum inflammatory factor levels without significant changes in blood lipids. Compared with model group, UTI reduced macrophage infiltration of iliac artery (13.91 \u00b1 2.03% vs 24.21 \u00b1 8.94%, P &lt; .01). Hyperlipidemia reduced the expression of miR-181b and increased NT and N\/M ratio. Systemic administration of UTI rescued miR-181b expression and inhibited neointimal formation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Urinary trypsin inhibitor could reduce neointimal hyperplasia by inhibiting inflammatory response induced by hyperlipidemia and may become a potential antiatherosclerosis supplement.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1074248415578907","type":"journal-article","created":{"date-parts":[[2015,4,20]],"date-time":"2015-04-20T21:23:07Z","timestamp":1429564987000},"page":"572-578","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Urinary Trypsin Inhibitor Reduced Inflammation Response Induced by Hyperlipidemia"],"prefix":"10.1177","volume":"20","author":[{"given":"Ying","family":"Deng","sequence":"first","affiliation":[{"name":"Department of Emergency, Second Affiliated Hospital of Harbin Medical University, Harbin, Hei Long Jiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junying","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Emergency, Second Affiliated Hospital of Harbin Medical University, Harbin, Hei Long Jiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,4,20]]},"reference":[{"key":"bibr1-1074248415578907","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.108.179705"},{"key":"bibr2-1074248415578907","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-8932(01)76390-7"},{"key":"bibr3-1074248415578907","doi-asserted-by":"publisher","DOI":"10.1038\/nature02871"},{"key":"bibr4-1074248415578907","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0707493105"},{"key":"bibr5-1074248415578907","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.110.206201"},{"key":"bibr6-1074248415578907","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1107052108"},{"key":"bibr7-1074248415578907","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvp121"},{"key":"bibr8-1074248415578907","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2010.16"},{"key":"bibr9-1074248415578907","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvp121"},{"key":"bibr10-1074248415578907","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1002120107"},{"key":"bibr11-1074248415578907","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.113.302089"},{"key":"bibr12-1074248415578907","doi-asserted-by":"publisher","DOI":"10.1097\/00024382-200115020-00004"},{"key":"bibr13-1074248415578907","doi-asserted-by":"publisher","DOI":"10.1159\/000018875"},{"key":"bibr14-1074248415578907","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199703000-00006"},{"key":"bibr15-1074248415578907","doi-asserted-by":"publisher","DOI":"10.1378\/chest.99.4.1055-b"},{"issue":"41","key":"bibr16-1074248415578907","first-page":"2893","volume":"88","author":"Jiang YF","year":"2008","journal-title":"Zhonghua Yi Xue Za Zhi"},{"issue":"2","key":"bibr17-1074248415578907","first-page":"107","volume":"35","author":"Zhou Q","year":"2010","journal-title":"Zhong Nan Da Xue Xue Bao Yi Xue Ban"},{"key":"bibr18-1074248415578907","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-012-0568-x"},{"key":"bibr19-1074248415578907","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2007.117382"},{"key":"bibr20-1074248415578907","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.17.10134"},{"key":"bibr21-1074248415578907","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.69.2.241"},{"key":"bibr22-1074248415578907","doi-asserted-by":"publisher","DOI":"10.1086\/315332"},{"key":"bibr23-1074248415578907","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.52.3.262"},{"issue":"4","key":"bibr24-1074248415578907","first-page":"497","volume":"48","author":"Bingyang J","year":"2007","journal-title":"J Cardiovasc Surg"},{"key":"bibr25-1074248415578907","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2008.10.006"},{"key":"bibr26-1074248415578907","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.028423"},{"key":"bibr27-1074248415578907","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2012.03.008"},{"key":"bibr28-1074248415578907","doi-asserted-by":"publisher","DOI":"10.4238\/2014.September.12.19"},{"key":"bibr29-1074248415578907","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12374"},{"issue":"7","key":"bibr30-1074248415578907","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/S0300-8932(02)76693-1","volume":"55","author":"P\u00e9rez Fern\u00e1ndez R","year":"2002","journal-title":"Rev Esp Cardiol"},{"issue":"6","key":"bibr31-1074248415578907","first-page":"1973","volume":"122","author":"Sun X","year":"2012","journal-title":"J Clin Invest"}],"container-title":["Journal of Cardiovascular Pharmacology and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1074248415578907","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1074248415578907","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1074248415578907","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:42:15Z","timestamp":1777394535000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1074248415578907"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,20]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["10.1177\/1074248415578907"],"URL":"https:\/\/doi.org\/10.1177\/1074248415578907","relation":{},"ISSN":["1074-2484","1940-4034"],"issn-type":[{"value":"1074-2484","type":"print"},{"value":"1940-4034","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,20]]}}}