{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T06:24:35Z","timestamp":1777530275621,"version":"3.51.4"},"reference-count":37,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2015,10,7]],"date-time":"2015-10-07T00:00:00Z","timestamp":1444176000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cardiovasc Pharmacol Ther"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>A superficial abdominal surgical incision elicits cardioprotection against cardiac ischemia\u2013reperfusion (I\/R) injury in mice. This process, called remote preconditioning of trauma (RPCT), has both an early and a late phase. Previous investigations have demonstrated that early RPCT reduces cardiac infarct size by 80% to 85%. We evaluated the cardioprotective and molecular mechanisms of late-phase RPCT in a murine I\/R injury model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Wild-type mice, bradykinin (BK) 2 receptor knockout mice, 3M transgenic mice (nuclear factor \u03baB [NF-\u03bab] repressor inhibitor of nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor alpha [I\u03baB\u03b1\n                      <jats:sup>(S32A, S36A, Y42F)<\/jats:sup>\n                      ]), and inducible nitric oxide synthase (iNOS) knockout mice were analyzed using a previously established I\/R injury model. A noninvasive abdominal surgical incision was made 24 hours prior to I\/R injury and the infarct size was determined at 24 hours post-I\/R injury.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The results indicated that a strong cardioprotective effect occurred during late-phase RPCT (58.42% \u00b1 1.89% sham vs 29.41% \u00b1 4.00% late RPCT, mean area of the infarct divided by the mean area of the risk region; P \u2264 .05; n = 10). Furthermore, pharmacological intervention revealed the involvement of neurogenic signaling in the beneficial effects of late RPCT via sensory and sympathetic thoracic nerves. Pharmacological experiments in transgenic mice-implicated BK receptors, \u03b2-adrenergic receptors, protein kinase C, and NF-\u03baB but not iNOS signaling in the cardioprotective effects of late RPCT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Late RPCT significantly decreased myocardial infarct size via neurogenic transmission and various other signaling pathways. This protective mechanism differentiates late and early RPCT. This study describes a new cardiac I\/R injury prevention method and refines the concept of RPCT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1074248415609435","type":"journal-article","created":{"date-parts":[[2015,10,8]],"date-time":"2015-10-08T20:29:41Z","timestamp":1444336181000},"page":"310-319","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["The Cardioprotective Effects of Late-Phase Remote Preconditioning of Trauma Depends on Neurogenic Pathways and the Activation of PKC and NF-\u03baB (But Not iNOS) in Mice"],"prefix":"10.1177","volume":"21","author":[{"given":"Y.","family":"Song","sequence":"first","affiliation":[{"name":"Hand and Microsurgery Center, The Second Affiliated Hospital of Harbin Medical University, Harbin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y. J.","family":"Ye","sequence":"additional","affiliation":[{"name":"Hand and Microsurgery Center, The Second Affiliated Hospital of Harbin Medical University, Harbin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. W.","family":"Li","sequence":"additional","affiliation":[{"name":"Hand and Microsurgery Center, The Second Affiliated Hospital of Harbin Medical University, Harbin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y. L.","family":"Zhao","sequence":"additional","affiliation":[{"name":"Hand and Microsurgery Center, The Second Affiliated Hospital of Harbin Medical University, Harbin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Q.","family":"Miao","sequence":"additional","affiliation":[{"name":"Hand and Microsurgery Center, The Second Affiliated Hospital of Harbin Medical University, Harbin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. Y.","family":"Hou","sequence":"additional","affiliation":[{"name":"Hand and Microsurgery Center, The Second Affiliated Hospital of Harbin Medical University, Harbin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X. 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