{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T02:20:36Z","timestamp":1780366836309,"version":"3.54.1"},"reference-count":61,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2016,1,26]],"date-time":"2016-01-26T00:00:00Z","timestamp":1453766400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cardiovasc Pharmacol Ther"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Impact of atrial fibrillation on clinical outcomes is well recognized, and application of renin\u2013angiotensin\u2013aldosterone system (RAAS) blockers for the prevention of atrial fibrillation (AF) is a theoretically appealing concept. However, clinical trials have yielded inconsistent results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A pooled study of 26 randomized controlled trials (RCTs) assessing the efficacy of RAAS blockers on AF prophylaxis was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 28 reports from 26 randomized controlled trials enrolled 165 387 patients, with an overall 24% reduction in the incidence of AF (odds ratio [OR]: 0.76, 95% confidence interval [CI]: 0.68-0.85], P = .000). Forty-nine percent reduction in the incidence of AF (OR: 0.51, 95% CI: 0.30-0.85, P = .010) in systolic heart failure was observed, whereas no significant effect was observed in patients with diastolic heart failure, postmyocardial infarction, and high cardiovascular disease risk. There was a 19% (OR: 0.81, 95% CI: 0.67-1.00, P = .037) reduction in new-onset and 54% (OR: 0.46, 95% CI: 0.33-0.62, P = .000) reduction in recurrent AF in hypertensive patients with 39% (OR: 0.61, 95% CI: 0.44-0.84, P = .003) risk reduction against calcium blockers and 41% (OR: 0.59, 95% CI: 0.44-0.80, P = .001) risk reduction against \u03b2 blockers. Angiotensin-receptor blocker appeared marginally superior to angiotensin-converting enzyme inhibitor in primary and secondary prevention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This study suggests that RAAS blockade effectively suppresses AF in systolic heart failure, and hypertensives derive greater benefit against new-onset and recurrent AF compared to \u03b2 blockers, calcium channel blockers, and diuretics.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1074248415619490","type":"journal-article","created":{"date-parts":[[2016,1,27]],"date-time":"2016-01-27T20:08:14Z","timestamp":1453925294000},"page":"388-404","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":52,"title":["Effects of RAAS Blockers on Atrial Fibrillation Prophylaxis"],"prefix":"10.1177","volume":"21","author":[{"given":"Sandip","family":"Chaugai","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Institute of Hypertension, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen Yeng","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Institute of Hypertension, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Ali Sepehry","sequence":"additional","affiliation":[{"name":"Graduate Program in Neuroscience, College for Interdisciplinary Studies, University of British Columbia, Vancouver, British Columbia, Canada"},{"name":"Department of Medicine, Division of Neurology, University of British Columbia, Vancouver, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,1,26]]},"reference":[{"key":"bibr1-1074248415619490","doi-asserted-by":"publisher","DOI":"10.1378\/chest.118.4.914"},{"key":"bibr2-1074248415619490","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(97)00194-0"},{"key":"bibr3-1074248415619490","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.06.080"},{"key":"bibr4-1074248415619490","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2008.02.025"},{"key":"bibr5-1074248415619490","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi505"},{"key":"bibr6-1074248415619490","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"bibr7-1074248415619490","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000100"},{"key":"bibr8-1074248415619490","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0b013e318160b42a"},{"key":"bibr9-1074248415619490","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2008.217"},{"key":"bibr10-1074248415619490","doi-asserted-by":"publisher","DOI":"10.1177\/1074248410395018"},{"key":"bibr11-1074248415619490","doi-asserted-by":"publisher","DOI":"10.1002\/clc.21994"},{"key":"bibr12-1074248415619490","doi-asserted-by":"publisher","DOI":"10.1177\/1470320312443909"},{"key":"bibr13-1074248415619490","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.37970.629537.0D"},{"key":"bibr14-1074248415619490","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(08)70198-4"},{"key":"bibr15-1074248415619490","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2007.04.062"},{"key":"bibr16-1074248415619490","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61242-8"},{"key":"bibr17-1074248415619490","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0805710"},{"key":"bibr18-1074248415619490","doi-asserted-by":"crossref","unstructured":"ACTIVE I Investigators, Yusuf S, Healey JS, Pogue J, Irbesartan in patients with atrial fibrillation. 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