{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T22:01:11Z","timestamp":1780092071806,"version":"3.54.0"},"reference-count":19,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2016,10,26]],"date-time":"2016-10-26T00:00:00Z","timestamp":1477440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cardiovasc Pharmacol Ther"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Furosemide is associated with poor prognosis in patients with heart failure and reduced ejection fraction (HFrEF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>To evaluate the association between daily furosemide dose prescribed during the dry state and long-term survival in stable, optimally medicated outpatients with HFrEF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Population and Methods:<\/jats:title>\n                    <jats:p>Two hundred sixty-six consecutive outpatients with left ventricular ejection fraction &lt;40%, clinically stable in the dry state and on optimal heart failure therapy, were followed up for 3 years in a heart failure unit. The end point was all-cause death. There were no changes in New York Heart Association class and therapeutics, including diuretics, and no decompensation or hospitalization during 6 months. Furosemide doses were categorized as low or none (0-40 mg\/d), intermediate (41-80 mg\/d), and high (&gt;80 mg). Cox regression was adjusted for significant confounders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The 3-year mortality rate was 33.8%. Mean dose of furosemide was 57.3 \u00b1 21.4 mg\/d. A total of 47.6% of patients received the low dose, 42.1% the intermediate dose, and 2.3% the high dose. Receiver operating characteristics for death associated with furosemide dose showed an area under the curve of 0.74 (95% confidence interval [CI]: 0.68-0.79; P &lt; .001), and the best cutoff was &gt;40 mg\/d. An increasing daily dose of furosemide was associated with worse prognosis. Those receiving the intermediate dose (hazard ratio [HR] = 4.1; 95% CI: 2.57-6.64; P &lt; .001) or high dose (HR = 19.8; 95% CI: 7.9-49.6; P &lt; .001) had a higher risk of mortality compared to those receiving a low dose. Patients receiving &gt;40 mg\/d, in a propensity score\u2013matched cohort, had a greater risk of mortality than those receiving a low dose (HR = 4.02; 95% CI: 1.8-8.8; P = .001) and those not receiving furosemide (HR = 3.9; 95% CI: 0.07-14.2; P = .039).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Furosemide administration during the dry state in stable, optimally medicated outpatients with HFrEF is unfavorably associated with long-term survival. The threshold dose was 40 mg\/d.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1074248416675613","type":"journal-article","created":{"date-parts":[[2016,10,26]],"date-time":"2016-10-26T20:49:27Z","timestamp":1477514967000},"page":"256-263","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Furosemide Prescription During the Dry State Is a Predictor of Long-Term Survival of Stable, Optimally Medicated Patients With Systolic Heart Failure"],"prefix":"10.1177","volume":"22","author":[{"given":"Luis","family":"Sargento","sequence":"first","affiliation":[{"name":"Heart Failure Unit, Cardiology Department, Lisbon North Hospital Centre, Pulido Valente Hospital, Lisbon, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre Vicente","family":"Sim\u00f5es","sequence":"additional","affiliation":[{"name":"Internal Medicine, Lisbon North Hospital Centre, Pulido Valente Hospital, Lisbon, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Longo","sequence":"additional","affiliation":[{"name":"Heart Failure Unit, Cardiology Department, Lisbon North Hospital Centre, Pulido Valente Hospital, Lisbon, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuno","family":"Lousada","sequence":"additional","affiliation":[{"name":"Heart Failure Unit, Cardiology Department, Lisbon North Hospital Centre, Pulido Valente Hospital, Lisbon, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto Palma dos","family":"Reis","sequence":"additional","affiliation":[{"name":"Heart Failure Unit, Cardiology Department, Lisbon North Hospital Centre, Pulido Valente Hospital, Lisbon, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,10,26]]},"reference":[{"key":"bibr1-1074248416675613","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfs105"},{"key":"bibr2-1074248416675613","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e31829e8807"},{"key":"bibr3-1074248416675613","doi-asserted-by":"publisher","DOI":"10.1002\/bdd.1874"},{"key":"bibr4-1074248416675613","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl193"},{"key":"bibr5-1074248416675613","doi-asserted-by":"publisher","DOI":"10.2143\/AC.58.6.2005315"},{"key":"bibr6-1074248416675613","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.462"},{"issue":"2","key":"bibr7-1074248416675613","first-page":"154","volume":"56","author":"Kapelios CJ","year":"2015","journal-title":"Hellenic J 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