{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:22:06Z","timestamp":1791944526227,"version":"4.3.4"},"reference-count":54,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2016,12,28]],"date-time":"2016-12-28T00:00:00Z","timestamp":1482883200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cardiovasc Pharmacol Ther"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:p>The novel combination sacubitril\/valsartan represents a new therapeutic approach in the management of heart failure. With the simultaneous blockage of the enzyme neprilysin (by sacubitril) and angiotensin II receptors (by valsartan), this combination reduces the degradation of natriuretic peptides and other counterregulatory peptide systems while avoiding the deleterious effect of angiotensin II receptors activation and thereby encompasses a beneficial impact of 2 important neurohormonal pathways activated in heart failure. As opposed to previously tested neprilysin inhibitors, sacubitril\/valsartan represents a more effective method in reducing morbidity and mortality in heart failure, while preserving a safety profile comparable to well-established, standard, angiotensin-converting enzyme inhibitor\u2019s therapy.<\/jats:p>","DOI":"10.1177\/1074248416683049","type":"journal-article","created":{"date-parts":[[2017,6,7]],"date-time":"2017-06-07T02:12:57Z","timestamp":1496801577000},"page":"356-364","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Angiotensin Receptor\u2013Neprilysin Inhibition"],"prefix":"10.1177","volume":"22","author":[{"given":"Ofer","family":"Havakuk","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine, LAC\/USC Medical Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uri","family":"Elkayam","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine, LAC\/USC Medical Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,12,28]]},"reference":[{"key":"bibr1-1074248416683049","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1409077"},{"key":"bibr2-1074248416683049","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.35.1.155"},{"key":"bibr3-1074248416683049","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.6.904"},{"key":"bibr4-1074248416683049","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0004(97)01086-4"},{"key":"bibr5-1074248416683049","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(01)00238-3"},{"key":"bibr6-1074248416683049","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2011.07.013"},{"key":"bibr7-1074248416683049","doi-asserted-by":"publisher","DOI":"10.1172\/JCI74281"},{"issue":"2","key":"bibr8-1074248416683049","first-page":"138","volume":"21","author":"Hinson JP","year":"2000","journal-title":"Endocr Rev"},{"key":"bibr9-1074248416683049","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(98)00159-4"},{"key":"bibr10-1074248416683049","doi-asserted-by":"publisher","DOI":"10.1159\/000368404"},{"key":"bibr11-1074248416683049","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs262"},{"key":"bibr12-1074248416683049","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)90714-9"},{"key":"bibr13-1074248416683049","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199203000-00011"},{"key":"bibr14-1074248416683049","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.1998.1201"},{"key":"bibr15-1074248416683049","doi-asserted-by":"publisher","DOI":"10.1007\/s002280050196"},{"key":"bibr16-1074248416683049","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199304000-00011"},{"key":"bibr17-1074248416683049","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)00741-5"},{"issue":"2","key":"bibr18-1074248416683049","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/S0022-3565(25)12124-1","volume":"275","author":"Trippodo NC","year":"1995","journal-title":"J Pharmacol Exp Ther"},{"key":"bibr19-1074248416683049","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000029801.86489.50"},{"key":"bibr20-1074248416683049","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0707641"},{"key":"bibr21-1074248416683049","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjhyper.2003.09.014"},{"key":"bibr22-1074248416683049","doi-asserted-by":"publisher","DOI":"10.1177\/0091270009343932"},{"key":"bibr23-1074248416683049","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61966-8"},{"key":"bibr24-1074248416683049","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0b013e318210fc7e"},{"issue":"23","key":"bibr25-1074248416683049","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1056\/NEJM198706043162301","volume":"316","author":"Effects of enalapril on mortality in severe congestive heart failure","year":"1987","journal-title":"N Engl J Med"},{"issue":"5","key":"bibr26-1074248416683049","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1056\/NEJM199108013250501","volume":"325","author":"Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure","year":"1991","journal-title":"N Engl J Med"},{"key":"bibr27-1074248416683049","unstructured":"ENTRESTO (sacubitril\/valsartan)[package insert]. East Hanover, NJ: Novartis Pharmaceuticals Corporation; 2015."},{"key":"bibr28-1074248416683049","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00982.x"},{"key":"bibr29-1074248416683049","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.060002715.x"},{"key":"bibr30-1074248416683049","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.232"},{"key":"bibr31-1074248416683049","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-016-2072-7"},{"key":"bibr32-1074248416683049","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.013748"},{"key":"bibr33-1074248416683049","doi-asserted-by":"publisher","DOI":"10.2174\/1567205012666141218140953"},{"key":"bibr34-1074248416683049","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2011.02.004"},{"key":"bibr35-1074248416683049","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.17632"},{"key":"bibr36-1074248416683049","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12861"},{"key":"bibr38-1074248416683049","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1208799"},{"key":"bibr39-1074248416683049","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu204"},{"key":"bibr40-1074248416683049","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61227-6"},{"key":"bibr41-1074248416683049","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.548"},{"key":"bibr42-1074248416683049","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.580"},{"key":"bibr43-1074248416683049","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2015.06.067"},{"key":"bibr44-1074248416683049","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv464"},{"key":"bibr45-1074248416683049","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.04.047"},{"key":"bibr46-1074248416683049","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv186"},{"key":"bibr47-1074248416683049","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv330"},{"key":"bibr48-1074248416683049","doi-asserted-by":"publisher","DOI":"10.1111\/ejhf.32"},{"key":"bibr49-1074248416683049","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.08.878"},{"key":"bibr50-1074248416683049","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2016.05.002"},{"key":"bibr53-1074248416683049","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2016.1747"},{"key":"bibr54-1074248416683049","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-132-10-200005160-00002"},{"key":"bibr55-1074248416683049","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsa051989"},{"key":"bibr56-1074248416683049","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.05.011"},{"key":"bibr57-1074248416683049","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw128"}],"container-title":["Journal of Cardiovascular Pharmacology and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1074248416683049","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1074248416683049","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1074248416683049","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:42:34Z","timestamp":1777394554000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.1177\/1074248416683049"}},"subtitle":["New Therapeutic Concept for the Management of Chronic Heart Failure: Development, Clinical Implications, and Future Perspectives"],"short-title":[],"issued":{"date-parts":[[2016,12,28]]},"references-count":54,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["10.1177\/1074248416683049"],"URL":"https:\/\/doi.org\/10.1177\/1074248416683049","relation":{},"ISSN":["1074-2484","1940-4034"],"issn-type":[{"value":"1074-2484","type":"print"},{"value":"1940-4034","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,28]]}}}