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The past decade has seen considerable improvements in diagnosis as well as treatment of various heart diseases. Various new therapeutic targets are being identified through in-depth knowledge of the disease mechanisms which has favored the testing of new strategies leading to newer treatment options. Opioid peptides and G-protein-coupled opioid receptors (ORs) have been previously studied widely in terms of central nervous system actions in mitigating the pain and drug abuse. The OR agonism or antagonism induces cytoprotective states in the myocardium, rendering these receptors as an attractive target for protection of heart from the fatal heart diseases. The opioids can provide an extended window of protection of the heart from various diseases. Although the mechanisms may not be fully understood, they seem to play a crucial role in various CVDs such as hypertension, hyperlipidemia, ischemic heart disease myocardial ischemia, and congestive heart failure. Since these compounds are already being used in acute and chronic pain, soon these compounds might be approved for use as cardioprotective agents. The following review focuses on the new information acquired on the role of the ORs in various CVDs.<\/jats:p>","DOI":"10.1177\/1074248418757009","type":"journal-article","created":{"date-parts":[[2018,3,11]],"date-time":"2018-03-11T22:22:15Z","timestamp":1520806935000},"page":"279-291","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":31,"title":["Opioids in Cardiovascular Disease: Therapeutic Options"],"prefix":"10.1177","volume":"23","author":[{"given":"Hemangi","family":"Rawal","sequence":"first","affiliation":[{"name":"Institute of Pharmacy, Nirma University, Ahmedabad, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0594-5452","authenticated-orcid":false,"given":"Bhoomika M.","family":"Patel","sequence":"additional","affiliation":[{"name":"Institute of Pharmacy, Nirma University, Ahmedabad, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,3,11]]},"reference":[{"key":"bibr1-1074248418757009","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61682-2"},{"issue":"5","key":"bibr2-1074248418757009","first-page":"24","volume":"28","author":"Koleva T","year":"1989","journal-title":"Vutur Boles"},{"key":"bibr3-1074248418757009","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvv201"},{"key":"bibr4-1074248418757009","first-page":"973723","volume":"2012","author":"Alexander T","year":"2012","journal-title":"Biochem Int"},{"key":"bibr5-1074248418757009","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2014.08.004"},{"key":"bibr6-1074248418757009","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-8206.2012.01051.x"},{"key":"bibr7-1074248418757009","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13042"},{"key":"bibr8-1074248418757009","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e318238bba6"},{"key":"bibr9-1074248418757009","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aer115"},{"key":"bibr10-1074248418757009","first-page":"496","volume-title":"Basic and Clinical Pharmacology","author":"Way WL","year":"1998"},{"key":"bibr11-1074248418757009","first-page":"2508","volume-title":"Harrison\u2019s Principles of Internal Medicine","author":"Schuckit MA","year":"1998","edition":"14"},{"key":"bibr12-1074248418757009","first-page":"329","volume-title":"Clinical Anesthesia","author":"Coda BA","year":"1997","edition":"3"},{"key":"bibr13-1074248418757009","doi-asserted-by":"publisher","DOI":"10.3390\/ph4030470"},{"key":"bibr14-1074248418757009","unstructured":"Global Health Observatory (GHO) data (2016). http:\/\/www.who.int\/gho\/ncd\/risk_factors\/blood_pressure_prevalence_\u00a0text\/en\/. 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