{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T02:40:33Z","timestamp":1790563233673,"version":"4.1.0"},"reference-count":41,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2018,4,15]],"date-time":"2018-04-15T00:00:00Z","timestamp":1523750400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cardiovasc Pharmacol Ther"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Inflammation plays a crucial role in the pathophysiology of myocardial ischemia\/reperfusion (I\/R) injury. A clinical trial has recently reported a smaller infarct size in a cohort of patients with ST-segment elevation myocardial infarction (MI) treated with a short colchicine course. The mechanism underlying colchicine-induced cardioprotection in the early MI phase remains unclear. We hypothesized that a short pretreatment with colchicine could induce acute beneficial effects by protecting the heart against inflammation in myocardial I\/R injury.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results:<\/jats:title>\n                    <jats:p>Rats were subjected to 40-minute left anterior descending coronary occlusion, followed by 120-minute reperfusion. Colchicine (0.3 mg\/kg) or a vehicle was administered per os 24 hours and immediately before surgery. Infarct size was significantly reduced in the colchicine group (35.6% \u00b1 3.0% vs 46.6% \u00b1 3.3%, P &lt; .05). The beneficial effects of colchicine were associated with an increased systemic interleukin-10 (IL-10) level and decreased cardiac transforming growth factor-\u03b2 level. Interleukin-1\u03b2 was found to increase in a \u201ctime of reperfusion\u201d-dependent manner. Colchicine inhibited messenger RNA expression of caspase-1 and pro-IL-18. Interleukin-1\u03b2 injected 10 minutes prior to myocardial ischemia induced greater infarct size (58.0% \u00b1 2.0%, P &lt; .05) as compared to the vehicle. Colchicine combined to IL-1\u03b2 injection significantly decreased infarct size (47.1% \u00b1 2.2%, P &lt; .05) as compared to IL-1\u03b2 alone, while colchicine alone exhibited a significantly more marked cardioprotective effect than the colchicine-IL-1\u03b2 association.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The cardioprotection induced by a short colchicine pretreatment was associated with an anti-inflammatory effect in the early reperfusion phase in our rat MI model.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1074248418763611","type":"journal-article","created":{"date-parts":[[2018,4,15]],"date-time":"2018-04-15T22:44:06Z","timestamp":1523832246000},"page":"446-455","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":44,"title":["Cardioprotective Role of Colchicine Against 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