{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T14:27:02Z","timestamp":1783607222302,"version":"3.55.0"},"reference-count":29,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2018,4,18]],"date-time":"2018-04-18T00:00:00Z","timestamp":1524009600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cardiovasc Pharmacol Ther"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Patients hospitalized with acute myocardial infarction (AMI) are often on prior single antiplatelet therapy (SAPT) or a dual antiplatelet therapy (DAPT). Whether chronic SAPT or DAPT is beneficial or associated with an increased risk in AMI is still controversial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results:<\/jats:title>\n                    <jats:p>We prospectively enrolled 1718 consecutive patients with AMI (798 ST-segment elevation myocardial infarction and 920 non-ST-segment elevation myocardial infarction) who were divided according to their chronic APT (no APT, SAPT, or DAPT). The study primary end point was the infarct size, as estimated by troponin I peak. Incidence of major bleeding was also evaluated. Five hundred thirty-six (31%) patients were on chronic SAPT and 215 (13%) on DAPT. A graded increase in Global Registry of Acute Coronary Events (GRACE) and Can Rapid risk stratification of Unstable angina patients Suppress ADverse outcomes with Early implementation of the ACC\/AHA guidelines (CRUSADE) risk scores was found going from patients without APT to those with DAPT, while a progressive smaller troponin I peak was observed with the increasing number of chronic antiplatelet agents (11.2 [interquartile range: 2-45] ng\/mL, 6.6 [1-33] ng\/mL, and 4.1 [1-24] ng\/mL; P &lt; .001 for trend). This result was maintained after adjustment for baseline ischemic risk profile (GRACE score) and other major confounders ( P &lt; .001). The incidence of bleeding was higher in patients on chronic APT than in those without APT (5.2% vs 2.4%; P = .002). However, when the bleeding risk was adjusted for the CRUSADE risk score, chronic SAPT (odds ratio [OR]: 1.40, 95% confidence interval [CI]: 0.77-2.53) and DAPT (OR: 0.70, 95% CI: 0.29-1.70) were not associated with an increased bleeding risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In patients with AMI, chronic APT is associated with higher baseline ischemic and bleeding risks. Despite this and unexpectedly, they have a smaller infarct size and similar adjusted bleeding risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1074248418769636","type":"journal-article","created":{"date-parts":[[2018,4,18]],"date-time":"2018-04-18T22:48:08Z","timestamp":1524091688000},"page":"407-413","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Impact of Chronic Antiplatelet Therapy on Infarct Size and Bleeding in Patients With Acute Myocardial Infarction"],"prefix":"10.1177","volume":"23","author":[{"given":"Jeness","family":"Campodonico","sequence":"first","affiliation":[{"name":"Centro Cardiologico Monzino, I.R.C.C.S, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Cosentino","sequence":"additional","affiliation":[{"name":"Centro Cardiologico Monzino, I.R.C.C.S, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Milazzo","sequence":"additional","affiliation":[{"name":"Centro Cardiologico Monzino, I.R.C.C.S, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara","family":"Rubino","sequence":"additional","affiliation":[{"name":"Centro Cardiologico Monzino, I.R.C.C.S, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"De Metrio","sequence":"additional","affiliation":[{"name":"Centro Cardiologico Monzino, I.R.C.C.S, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"Marana","sequence":"additional","affiliation":[{"name":"Centro Cardiologico Monzino, I.R.C.C.S, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Moltrasio","sequence":"additional","affiliation":[{"name":"Centro Cardiologico Monzino, I.R.C.C.S, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Grazi","sequence":"additional","affiliation":[{"name":"Centro Cardiologico Monzino, I.R.C.C.S, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianfranco","family":"Lauri","sequence":"additional","affiliation":[{"name":"Centro Cardiologico Monzino, I.R.C.C.S, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Bonomi","sequence":"additional","affiliation":[{"name":"Centro Cardiologico Monzino, I.R.C.C.S, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Veglia","sequence":"additional","affiliation":[{"name":"Centro Cardiologico Monzino, I.R.C.C.S, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Chiorino","sequence":"additional","affiliation":[{"name":"Centro Cardiologico Monzino, I.R.C.C.S, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio","family":"Assanelli","sequence":"additional","affiliation":[{"name":"Centro Cardiologico Monzino, I.R.C.C.S, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio L.","family":"Bartorelli","sequence":"additional","affiliation":[{"name":"Centro Cardiologico Monzino, I.R.C.C.S, Milan, Italy"},{"name":"Department of Biomedical and Clinical Sciences \u201cLuigi Sacco,\u201d University of Milan, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4410-4461","authenticated-orcid":false,"given":"Giancarlo","family":"Marenzi","sequence":"additional","affiliation":[{"name":"Centro Cardiologico Monzino, I.R.C.C.S, Milan, 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