{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T06:28:03Z","timestamp":1777530483955,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2018,8,6]],"date-time":"2018-08-06T00:00:00Z","timestamp":1533513600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100000659","name":"Research Trainees Coordinating Centre","doi-asserted-by":"crossref","award":["DRF-2011-04-080"],"award-info":[{"award-number":["DRF-2011-04-080"]}],"id":[{"id":"10.13039\/501100000659","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cardiovasc Pharmacol Ther"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>In the follow-up of patients in a trial of intracoronary sodium nitrite given during primary percutaneous coronary intervention (PCI) after acute myocardial infarction (AMI), we found a reduction in the incidence of major adverse cardiac events (MACEs). Specifically, MACE rates were 5.2% versus 25.0% with placebo at 3 years ( P = .013). Such MACE reductions should also be associated with economic benefit. Thus, we assessed the cost utility of sodium nitrite therapy versus standard primary PCI only.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results:<\/jats:title>\n                    <jats:p>We developed a model to simulate costs and quality-adjusted life years (QALYs) over the first 36 months after ST-Segment Elevation Myocardial Infarction (STEMI). Decision tree analysis was used to assess different potential cardiovascular outcomes after STEMI for patients in both treatment groups. Model inputs were derived from the NITRITE-AMI study. Cost of comparative treatments and follow-up in relation to cardiovascular events was calculated from the United Kingdom National Health Service perspective. Higher procedural costs for nitrite treatment were offset by lower costs for repeat revascularization, myocardial infarction, and hospitalization for heart failure compared to primary PCI plus placebo. Nitrite treatment was associated with higher utility values (0.91 \u00b1 0.19 vs 0.82 \u00b1 0.30, P = .041). The calculated incremental cost-effectiveness ratio of \u00a32177 per QALY indicates a cost-effective strategy. Furthermore, positive results were maintained when input parameters varied, indicating the robustness of our model. In fact, based on the difference in utility values, the cost of nitrite could increase by 4-fold (\u00a32006 per vial) and remain cost-effective.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This first analysis of sodium nitrite as a cardioprotective treatment demonstrates cost-effectiveness. Although more comparative analysis and assessment of longer follow-up times are required, our data indicate the considerable potential of nitrite-mediated cardioprotection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1074248418784940","type":"journal-article","created":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T01:32:00Z","timestamp":1533605520000},"page":"113-119","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Sodium Nitrite\u2013Mediated Cardioprotection in Primary Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction: A Cost-Effectiveness Analysis"],"prefix":"10.1177","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1441-0417","authenticated-orcid":false,"given":"Daniel A.","family":"Jones","sequence":"first","affiliation":[{"name":"Barts NIHR Biomedical Research Centre, Barts and The London Medical School, Queen Mary University, London, United Kingdom"},{"name":"Barts Interventional Group, Barts Heart Centre, Barts Health NHS Trust, London, United Kingdom"},{"name":"Department of Health Policy, London School of Economics and Political Science, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Whittaker","sequence":"additional","affiliation":[{"name":"Department of Health Policy, London School of Economics and Political Science, London, United Kingdom"},{"name":"Department of Emergency Medicine, Cardiovascular Research Institute, Wayne State University, Detroit, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krishnaraj S.","family":"Rathod","sequence":"additional","affiliation":[{"name":"Barts NIHR Biomedical Research Centre, Barts and The London Medical School, Queen Mary University, London, United Kingdom"},{"name":"Barts Interventional Group, Barts Heart Centre, Barts Health NHS Trust, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy J.","family":"Richards","sequence":"additional","affiliation":[{"name":"Barts Interventional Group, Barts Heart Centre, Barts Health NHS Trust, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mervyn","family":"Andiapen","sequence":"additional","affiliation":[{"name":"Barts Interventional Group, Barts Heart Centre, Barts Health NHS Trust, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sotiris","family":"Antoniou","sequence":"additional","affiliation":[{"name":"Barts Interventional Group, Barts Heart Centre, Barts Health NHS Trust, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Mathur","sequence":"additional","affiliation":[{"name":"Barts NIHR Biomedical Research Centre, Barts and The London Medical School, Queen Mary University, London, United Kingdom"},{"name":"Barts Interventional Group, Barts Heart Centre, Barts Health NHS Trust, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amrita","family":"Ahluwalia","sequence":"additional","affiliation":[{"name":"Barts NIHR Biomedical Research Centre, Barts and The London Medical School, Queen Mary University, London, United Kingdom"},{"name":"Barts Interventional Group, Barts Heart Centre, Barts Health NHS Trust, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,8,6]]},"reference":[{"key":"bibr1-1074248418784940","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.305082"},{"key":"bibr2-1074248418784940","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2016-309748"},{"key":"bibr3-1074248418784940","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2013-002813"},{"key":"bibr4-1074248418784940","doi-asserted-by":"publisher","DOI":"10.3109\/07853890109002087"},{"key":"bibr5-1074248418784940","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199711000-00002"},{"key":"bibr6-1074248418784940","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2006.111401"},{"issue":"1","key":"bibr7-1074248418784940","doi-asserted-by":"crossref","first-page":"22","DOI":"10.33590\/emjcardiol\/10311664","volume":"3","author":"Annemans L","year":"2015","journal-title":"EMJ Cardiol"},{"key":"bibr8-1074248418784940","unstructured":"Department of Health. 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