{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T06:29:23Z","timestamp":1777530563164,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2019,7,7]],"date-time":"2019-07-07T00:00:00Z","timestamp":1562457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cardiovasc Pharmacol Ther"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The oral vasopressin-2 receptor antagonist, tolvaptan, causes aquaresis and improves symptoms in patients with congestive heart failure. However, few studies have explored the effect of tolvaptan in acute heart failure (AHF) patients \u226590 years old.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This study enrolled 106 AHF patients treated with tolvaptan added to standard therapy. The subjects were divided into 2 groups: \u226590-year-old patients (over-90 group, mean 92 \u00b1 2 years, n = 45) and &lt;90-year-old patients (under-90 group, mean 76 \u00b1 11 years, n = 61). Patients\u2019 characteristics were assessed, and efficacy and safety were compared between the 2 groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The over-90 group had a lower proportion of male patients, lower body weight, and higher ejection fraction. The under-90 group had significantly higher prevalence of ischemic heart disease and diabetes mellitus. There were no significant differences between the 2 groups in total urine volume at 24 and 48 hours (1934 \u00b1 983 mL vs 1816 \u00b1 1028 mL, P = 0.58 and 3806 \u00b1 1444 mL vs 4078 \u00b1 1851 mL, P=0.47, respectively), the mean change in body weight (\u22123.0 \u00b1 2.7 kg vs \u22122.6 \u00b1 2.6 kg, P = 0.50), improvement of congestive symptoms, changes in serum sodium and creatinine levels, the incidences of hypernatremia (n = 0, 0% vs n = 1, 1.6%, P = 0.63), and worsening renal function (n = 9, 20% vs n = 17, 28%, P = 0.48).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The efficacy and safety of tolvaptan in AHF patients aged more than 90 years were comparable to those of &lt;90 years old. Tolvaptan provides a complementary therapeutic option for AHF patients aged more than 90 years.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1074248419861962","type":"journal-article","created":{"date-parts":[[2019,7,8]],"date-time":"2019-07-08T01:01:49Z","timestamp":1562547709000},"page":"47-56","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Efficacy and Safety of Tolvaptan in Patients More Than 90 Years Old With Acute Heart Failure"],"prefix":"10.1177","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2897-4766","authenticated-orcid":false,"given":"Yusuke","family":"Sato","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan"},{"name":"Depatment of Cardiology, Hikone Municipal Hospital, Shiga, 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