{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T20:13:43Z","timestamp":1779912823151,"version":"3.53.1"},"reference-count":53,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2019,8,12]],"date-time":"2019-08-12T00:00:00Z","timestamp":1565568000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cardiovasc Pharmacol Ther"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Anticoagulation therapy is recommended for stroke prevention in high-risk patients with atrial fibrillation (AF). This study aimed to estimate the time to switch from warfarin to a direct oral anticoagulant (DOAC) and identify the factors associated with it.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>By using claims data, we studied 7111 warfarin-using patients with nonvalvular AF who were aged \u226565 years. The Kaplan-Meier analysis was performed to estimate the time to switch from warfarin to a DOAC, and Cox proportional hazard regression analysis was used to estimate the influencing factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Approximately one-third of the patients (2403, 33.8%) switched from warfarin to a DOAC during the study period. Female sex, aged between 75 and 79 years, having a Medical Aid or Patriots and Veterans Insurance, hypertension, and history of prior stroke, and transient ischemic attack or thromboembolism (prior stroke\/TIA\/TE) were associated with a significantly shorter time to switch. The odds of switching to a DOAC were increased by approximately 1.2-fold in the women and 1.4-fold in the patients with prior stroke\/TIA\/TE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Approximately one-third of the warfarin-using patients switched from warfarin to a DOAC within 6 months after the change in the DOAC reimbursement criteria. In the Cox proportional hazard regression analysis, the factors that affected anticoagulant switching from warfarin to a DOAC were female sex and history of prior stroke\/TIA\/TE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1074248419868996","type":"journal-article","created":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T00:30:52Z","timestamp":1565656252000},"page":"57-64","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Factors That Affect Time to Switch From Warfarin to a Direct Oral Anticoagulant After Change in the Reimbursement Criteria in Patients With Atrial Fibrillation"],"prefix":"10.1177","volume":"25","author":[{"given":"Susin","family":"Park","sequence":"first","affiliation":[{"name":"College of Pharmacy, Pusan National University, Busan, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0299-5131","authenticated-orcid":false,"given":"Nam Kyung","family":"Je","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Pusan National University, Busan, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,8,12]]},"reference":[{"key":"bibr1-1074248419868996","volume-title":"The Heart: Arteries and Veins","author":"Hurst JW","year":"1994","edition":"8"},{"key":"bibr2-1074248419868996","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198204293061703"},{"key":"bibr3-1074248419868996","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.84.2.469"},{"key":"bibr4-1074248419868996","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.002329"},{"key":"bibr5-1074248419868996","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.06.177"},{"key":"bibr6-1074248419868996","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2012.12.093"},{"key":"bibr7-1074248419868996","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61774-8"},{"key":"bibr8-1074248419868996","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.10.946"},{"key":"bibr9-1074248419868996","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs469"},{"key":"bibr10-1074248419868996","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(02)01236-6"},{"key":"bibr11-1074248419868996","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.28.10.973"},{"key":"bibr12-1074248419868996","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.22.8.983"},{"key":"bibr13-1074248419868996","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-146-12-200706190-00007"},{"key":"bibr14-1074248419868996","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.03.022"},{"key":"bibr15-1074248419868996","doi-asserted-by":"publisher","DOI":"10.4070\/kcj.2015.45.1.9"},{"issue":"1","key":"bibr16-1074248419868996","first-page":"50","volume":"70","author":"Kirchhof P","year":"2017","journal-title":"Rev Esp Cardiol (Engl Ed)"},{"key":"bibr17-1074248419868996","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2018.06.1043"},{"key":"bibr18-1074248419868996","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2018.07.040"},{"key":"bibr19-1074248419868996","author":"January CT","year":"2019","journal-title":"Heart Rhythm"},{"key":"bibr20-1074248419868996","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs253"},{"key":"bibr21-1074248419868996","doi-asserted-by":"publisher","DOI":"10.3904\/kjm.2018.93.2.87.e1"},{"key":"bibr22-1074248419868996","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.06.019"},{"key":"bibr23-1074248419868996","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2017.11.046"},{"key":"bibr24-1074248419868996","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2015.10.001"},{"issue":"1","key":"bibr25-1074248419868996","first-page":"49","volume":"104","author":"Ahrens I","year":"2010","journal-title":"Thromb Haemost"},{"key":"bibr26-1074248419868996","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.004747"},{"issue":"2","key":"bibr27-1074248419868996","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1161\/CIRCULATIONAHA.113.005008","volume":"130","author":"Halperin JL","year":"2014","journal-title":"Circulation"},{"key":"bibr28-1074248419868996","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu046"},{"key":"bibr29-1074248419868996","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.003432"},{"key":"bibr30-1074248419868996","doi-asserted-by":"publisher","DOI":"10.1016\/j.joa.2017.05.004"},{"issue":"20","key":"bibr31-1074248419868996","first-page":"e0189495","volume":"12","author":"Lee SR","year":"2017","journal-title":"PLoS One"},{"key":"bibr32-1074248419868996","doi-asserted-by":"publisher","DOI":"10.1111\/jcpt.12481"},{"key":"bibr33-1074248419868996","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2017012377"},{"key":"bibr34-1074248419868996","doi-asserted-by":"publisher","DOI":"10.5603\/KP.a2018.0027"},{"key":"bibr35-1074248419868996","doi-asserted-by":"publisher","DOI":"10.4070\/kcj.2017.0389"},{"key":"bibr36-1074248419868996","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0198674"},{"key":"bibr37-1074248419868996","unstructured":"Service NHI. National Health Insurance System of Korea. 2015. www.kobia.kr\/skin\/bbs\/downloads_e2\/download.php?tbl=policy_report&no=401. Accessed March 25, 2019."},{"key":"bibr38-1074248419868996","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.19.2365"},{"key":"bibr39-1074248419868996","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2015.03.031"},{"key":"bibr40-1074248419868996","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.12625"},{"key":"bibr41-1074248419868996","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2008.0991"},{"key":"bibr42-1074248419868996","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2017.07.002"},{"issue":"3","key":"bibr43-1074248419868996","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.ahj.2014.06.005","volume":"168","author":"Goto S","year":"2014","journal-title":"Am Heart J"},{"key":"bibr44-1074248419868996","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.002968"},{"key":"bibr45-1074248419868996","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.000990"},{"key":"bibr46-1074248419868996","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-15-1082"},{"key":"bibr47-1074248419868996","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70274-X"},{"key":"bibr48-1074248419868996","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70092-3"},{"key":"bibr49-1074248419868996","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70042-X"},{"key":"bibr50-1074248419868996","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.116.013540"},{"key":"bibr51-1074248419868996","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25489"},{"key":"bibr52-1074248419868996","doi-asserted-by":"publisher","DOI":"10.2147\/PPA.S152584"},{"key":"bibr53-1074248419868996","doi-asserted-by":"publisher","DOI":"10.4178\/epih\/e2014008"}],"container-title":["Journal of Cardiovascular Pharmacology and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1074248419868996","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1074248419868996","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1074248419868996","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:43:05Z","timestamp":1777394585000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1074248419868996"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,12]]},"references-count":53,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1177\/1074248419868996"],"URL":"https:\/\/doi.org\/10.1177\/1074248419868996","relation":{},"ISSN":["1074-2484","1940-4034"],"issn-type":[{"value":"1074-2484","type":"print"},{"value":"1940-4034","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,12]]}}}