{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T06:29:51Z","timestamp":1777530591598,"version":"3.51.4"},"reference-count":32,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T00:00:00Z","timestamp":1573516800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"crossref","award":["09\/54225-8"],"award-info":[{"award-number":["09\/54225-8"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cardiovasc Pharmacol Ther"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:p>\n                    We previously showed that digitoxin prolongs the survival of rats with heart failure due to myocardial infarction (MI). In this study, we evaluated the effect of digitoxin on myocardial structure, ventricular function, and proteins involved in calcium kinetics. Seventy-two rats with MI &gt;35% of the left ventricle were randomly assigned to 4 treatment groups: sham (n = 15), digitoxin (n = 11), infarction (n = 20), and infarction + digitoxin (n = 26). The rats were assessed 120 days after surgery by echocardiogram, hemodynamics, papillary muscle mechanics, collagen content, cardiomyocyte nuclear volume, and Western blot analysis of proteins involved in calcium kinetics. Digitoxin was administered via the rat chow. Two-way analysis of variance was used for comparisons. Myocardial infarction caused inotropic impairment, pulmonary congestion, increase of nuclear volume, myocardial collagen, and Na\n                    <jats:sup>+<\/jats:sup>\n                    \/Ca2\n                    <jats:sup>+<\/jats:sup>\n                    exchanger levels, and decreased SERCA2 and phosphorylated phospholamban levels. Treatment with digitoxin showed improvements in cardiac remodeling, inotropism, ventricular performance, pulmonary congestion, collagen accumulation, nuclear volume, and proteins involved in calcium kinetics. In rats with heart failure due to MI, long-term treatment with digitoxin attenuates congestive heart failure, mitigates myocardial remodeling and contractile impairment, and preserves myocardial levels of proteins involved in calcium kinetics.\n                  <\/jats:p>","DOI":"10.1177\/1074248419887708","type":"journal-article","created":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T09:17:13Z","timestamp":1573550233000},"page":"265-272","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Digitoxin Attenuates Heart Failure, Reduces Myocardial Hypertrophy, and Preserves the Calcium-Binding Proteins in Infarcted Rats"],"prefix":"10.1177","volume":"25","author":[{"given":"Camila T.","family":"Picollo","sequence":"first","affiliation":[{"name":"Cardiology Division, Department of Medicine, Federal University of S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra A. dos","family":"Santos","sequence":"additional","affiliation":[{"name":"Cardiology Division, Department of Medicine, Federal University of S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ednei L.","family":"Antonio","sequence":"additional","affiliation":[{"name":"Cardiology Division, Department of Medicine, Federal University of S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jairo M. A.","family":"Silva","sequence":"additional","affiliation":[{"name":"Cardiology Division, Department of Medicine, Federal University of S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danilo","family":"Bocalini","sequence":"additional","affiliation":[{"name":"S\u00e3o Judas University, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrey Jorge","family":"Serra","sequence":"additional","affiliation":[{"name":"Cardiology Division, Department of Medicine, Federal University of S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia S. M.","family":"Ihara","sequence":"additional","affiliation":[{"name":"Department of Pathology, Federal University of S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9793-670X","authenticated-orcid":false,"given":"Paulo J. 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