{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T06:30:28Z","timestamp":1777530628306,"version":"3.51.4"},"reference-count":32,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T00:00:00Z","timestamp":1589155200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"crossref","award":["R01HL133167"],"award-info":[{"award-number":["R01HL133167"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cardiovasc Pharmacol Ther"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>\n                      Hydrogen sulfide (H\n                      <jats:sub>2<\/jats:sub>\n                      S) protects against ischemic and inflammatory injury following myocardial ischemia via induction of microRNA (miR)-21. We sought to determine whether H\n                      <jats:sub>2<\/jats:sub>\n                      S attenuates ischemic heart failure with reduced ejection fraction (HFrEF) and interrogate the role of cofilin-2, a target of miR-21, in this protective process.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results:<\/jats:title>\n                    <jats:p>\n                      Adult male mice underwent myocardial infarction (MI) by coronary artery ligation after baseline echocardiography. Following MI, mice were treated with Na\n                      <jats:sub>2<\/jats:sub>\n                      S (100 \u03bcg\/kg\/day; intraperitoneal [IP]) or saline up to 28 days. End-diastolic pressure, measured by Millar catheter, was significantly increased ( P &lt; .05 vs sham) at 3 days post-MI in the saline group, which was attenuated with Na\n                      <jats:sub>2<\/jats:sub>\n                      S. Left ventricular (LV) fractional shortening decreased significantly at 28 days post-MI in the saline group but was preserved with Na\n                      <jats:sub>2<\/jats:sub>\n                      S and LV infarct scar size was smaller in Na\n                      <jats:sub>2<\/jats:sub>\n                      S group as compared to control. Apoptotic signaling, measured by Bcl-2\/Bax ratio, was significantly increased in the saline group but was mitigated with Na\n                      <jats:sub>2<\/jats:sub>\n                      S. Survival rate was 2-fold higher in Na\n                      <jats:sub>2<\/jats:sub>\n                      S group compared to saline control ( P &lt; .05). Proteomic analysis and Matrix-Assisted Laser Desorption\/Ionization-Time of Flight (TOF)\/TOF tandem mass spectrometry identified significant changes in proapoptotic cofilin-2 expression, a specific target of miR-21, between saline- and sodium sulfide -treated mice at 28 days post-MI. Western blot analysis confirmed a significant increase in cofilin-2 after MI, which was suppressed with Na\n                      <jats:sub>2<\/jats:sub>\n                      S treatment. Chronic Na\n                      <jats:sub>2<\/jats:sub>\n                      S treatment also attenuated inflammasome formation and activation leading to reduction of maladaptive signaling.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      Na\n                      <jats:sub>2<\/jats:sub>\n                      S treatment after MI preserves LV function and improves survival through attenuation of inflammasome-mediated adverse remodeling. We propose H\n                      <jats:sub>2<\/jats:sub>\n                      S donors as promising therapeutic tools for ischemic HFrEF.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1074248420923542","type":"journal-article","created":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T06:10:06Z","timestamp":1589177406000},"page":"472-483","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["Hydrogen Sulfide Therapy Suppresses Cofilin-2 and Attenuates Ischemic Heart Failure in a Mouse Model of Myocardial Infarction"],"prefix":"10.1177","volume":"25","author":[{"given":"Khoa","family":"Nguyen","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, VCU Pauley Heart Center, Virginia Commonwealth University, Richmond, VA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinh Q.","family":"Chau","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, VCU Pauley Heart Center, Virginia Commonwealth University, Richmond, VA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adolfo G.","family":"Mauro","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, VCU Pauley Heart Center, Virginia Commonwealth University, Richmond, VA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Durrant","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, VCU Pauley Heart Center, Virginia Commonwealth University, Richmond, VA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Toldo","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, VCU Pauley Heart Center, Virginia Commonwealth University, Richmond, VA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Abbate","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, VCU Pauley Heart Center, Virginia Commonwealth University, Richmond, VA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anindita","family":"Das","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, VCU Pauley Heart Center, Virginia Commonwealth University, Richmond, VA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8947-9315","authenticated-orcid":false,"given":"Fadi N.","family":"Salloum","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, VCU Pauley Heart Center, Virginia Commonwealth University, Richmond, VA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,5,11]]},"reference":[{"key":"bibr1-1074248420923542","doi-asserted-by":"crossref","unstructured":"Szab\u00f3 G, Veres G, Radovits T, et al. 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