{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:30:39Z","timestamp":1790256639552,"version":"4.1.0"},"reference-count":45,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2020,6,5]],"date-time":"2020-06-05T00:00:00Z","timestamp":1591315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"crossref","award":["NHMRC project grant 1066242"],"award-info":[{"award-number":["NHMRC project grant 1066242"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cardiovasc Pharmacol Ther"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>We investigated long-term adherence to renin\u2013angiotensin system inhibitors (RASIs) and \u03b2-blockers, and associated predictors, in senior patients after hospitalization for heart failure (HF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A population-based data set identified 4488 patients who survived 60 days following their index hospitalization for HF in Western Australia from 2003 to 2008 with a 3-year follow-up. Their person-linked Pharmaceutical Benefits Scheme records identified medications dispensed during follow-up. Drug discontinuation was defined as the first break \u226590 days following the previous supply. Medication adherence was calculated using the proportion of days covered (PDC), with PDC \u2265 80% defined as being adherent. Multivariable logistic regression models were used to identify predictors of PDC &lt; 80%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In the cohort (57% male, mean age: 76.6 years), 77.4% were dispensed a RASI and 52.7% a \u03b2-blocker within 60 days postdischarge. Over the 3-year follow-up, 28% and 42% of patients discontinued RASI and \u03b2-blockers, respectively. Only 64.6% and 47.5% of RASI and \u03b2-blocker users, respectively, were adherent to their treatment over 3 years, with adherence decreasing over time (trend P &lt; .0001 for RASI and trend P = .02 for \u03b2-blockers). Older age, increasing Charlson comorbidity score, chronic kidney disease, and chronic obstructive pulmonary disease were independent predictors of PDC &lt; 80% for both drug groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Among seniors hospitalized for HF, discontinuation gaps were common for RASI and \u03b2-blockers postdischarge, and long-term adherence to these medications was suboptimal. Where appropriate, strategies to improve long-term medication adherence are indicated in HF patients, particularly in elderly patients with comorbidities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1074248420931617","type":"journal-article","created":{"date-parts":[[2020,6,5]],"date-time":"2020-06-05T06:16:58Z","timestamp":1591337818000},"page":"531-540","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Long-Term Adherence to Renin\u2013Angiotensin System Inhibitors and \u03b2-Blockers After Heart Failure Hospitalization in Senior Patients"],"prefix":"10.1177","volume":"25","author":[{"given":"Xiwen","family":"Qin","sequence":"first","affiliation":[{"name":"School of Population and Global Health, The University of Western Australia, Perth, Western Australia, 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