{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T07:31:21Z","timestamp":1782891081546,"version":"3.54.5"},"reference-count":17,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T00:00:00Z","timestamp":1596499200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cardiovasc Pharmacol Ther"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:p>To determine the effect renin-angiotensin system blockers on the outcome in patients with hypertension and concurrent COVID-19 infection, we searched PubMed, the Cochrane Library, and Google Scholar for relevant articles. Twelve studies with a total of 16,101 patients met the inclusion criteria. The mortality rate among the users of angiotensin converting enzyme inhibitors or angiotensin receptor blockers was 12.15% and in non-users it was 14.56% (risk ratio 0.70, 95% CI [0.53-0.91], P &lt; 0.007). There was no difference in the risk of death between the use of angiotensin converting enzyme inhibitors and angiotensin receptor blockers (risk ratio 1.09, 95% CI [0.90 -1.32]). We conclude that the use of angiotensin converting enzyme inhibitors and angiotensin receptor blockers improves mortality in patients with hypertension and concurrent COVID-19 infection, without a significant difference between ACEIs and ARBs in this population.<\/jats:p>","DOI":"10.1177\/1074248420947628","type":"journal-article","created":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T06:29:39Z","timestamp":1596522579000},"page":"503-507","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Renin-Angiotensin System Blockade and Mortality in Patients With Hypertension and COVID-19 Infection"],"prefix":"10.1177","volume":"25","author":[{"given":"Husam M.","family":"Salah","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guisseppe","family":"Calcaterra","sequence":"additional","affiliation":[{"name":"Post Graduate Medical School, University of Palermo, Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0384-2097","authenticated-orcid":false,"given":"Jawahar L.","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,8,4]]},"reference":[{"key":"bibr1-1074248420947628","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2012-7"},{"key":"bibr2-1074248420947628","doi-asserted-by":"publisher","DOI":"10.1093\/ehjcvp\/pvaa064"},{"key":"bibr3-1074248420947628","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.1161\/hyp.76.suppl_1.P002","volume":"76","author":"Feng Z","year":"2020","journal-title":"Hypertension"},{"key":"bibr4-1074248420947628","author":"Khera R","year":"2020","journal-title":"MedRxiv"},{"key":"bibr5-1074248420947628","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa433"},{"key":"bibr6-1074248420947628","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.104927"},{"key":"bibr7-1074248420947628","first-page":"e13","volume":"76","author":"Xiaoming G","year":"2020","journal-title":"Hypertension"},{"key":"bibr8-1074248420947628","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.15312"},{"key":"bibr9-1074248420947628","doi-asserted-by":"crossref","unstructured":"Ip A, Parikh K, Parrillo JE, et al. Hypertension and renin-angiotensin-aldosterone system inhibitors in patients with Covid-19. 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