{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T06:18:46Z","timestamp":1777529926942,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2020,11,7]],"date-time":"2020-11-07T00:00:00Z","timestamp":1604707200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Angers Loire metropole","award":["MPIA"],"award-info":[{"award-number":["MPIA"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cardiovasc Pharmacol Ther"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Galvanic current-induced vasodilation (CIV) is impaired in patients under low-dose aspirin (ASA; \u2264 500 mg\/day), but potential covariates and the impact of the time since the last ASA intake are unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>We used tissue viability imaging (TiVi) in patients at risk of cardiovascular disease and examined its association with self-reported treatments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients\/Methods:<\/jats:title>\n                    <jats:p>We recorded the age, gender, height, weight, smoking status, and use of 14 different drug categories in 822 patients either with known peripheral artery disease or at risk thereof. The difference between TiVi arbitrary units (TAUs) where stimulation was applied and an adjacent skin area was recorded, as well as the time since the last ASA intake. Step-by-step regression analysis was used to determine the factors that affect CIV amplitude.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results and Conclusions:<\/jats:title>\n                    <jats:p>CIV was 28.2 \u00b1 22.9 vs. 14.6 \u00b1 18.0 TAUs ( P &lt; 0.001) in patients treated with ASA (n = 287) and not treated with ASA (n = 535), respectively. The main determinants of CIV amplitude, by order of importance, were: aspirin intake, diabetes mellitus, age, and male sex. In ASA-treated patients, the main determinants were diabetes mellitus, time since the last ASA intake, male gender, and age. Non-invasive determination of the physiological effects of low-dose ASA is feasible in routine clinical practice. It could be a clinical approach to provide objective evidence of ASA intake, and potentially could be used to test adherence to treatment in ASA-treated patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1074248420971165","type":"journal-article","created":{"date-parts":[[2020,11,7]],"date-time":"2020-11-07T07:15:51Z","timestamp":1604733351000},"page":"269-278","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Current-Induced Vasodilation Specifically Detects, and Correlates With the Time Since, Last Aspirin Intake: An Interventional Study of 830 Patients"],"prefix":"10.1177","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1288-8866","authenticated-orcid":false,"given":"Pierre","family":"Ramondou","sequence":"first","affiliation":[{"name":"Vascular Medicine, Angers University Hospital, Angers, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanne","family":"Hersant","sequence":"additional","affiliation":[{"name":"Vascular Medicine, Angers University Hospital, Angers, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Fouquet","sequence":"additional","affiliation":[{"name":"Cardiac Surgery, Angers University Hospital, Angers, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendsendate Yves","family":"Sempore","sequence":"additional","affiliation":[{"name":"Sports and Exercise Medicine, Angers University Hospital, Angers, France"},{"name":"UMR CNRS 1083 INSERM 6015, LUNAM University, Angers, France"},{"name":"Universit\u00e9 Nazi Boni, Bobo Dioulasso, Burkina Faso"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Abraham","sequence":"additional","affiliation":[{"name":"Sports and Exercise Medicine, Angers University Hospital, Angers, France"},{"name":"UMR 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