{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T06:31:43Z","timestamp":1777530703155,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T00:00:00Z","timestamp":1618185600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cardiovasc Pharmacol Ther"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>There is a lack of robust data evaluating outcomes of enoxaparin \u201cbridge\u201d therapy in left ventricular assist device (LVAD) patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We performed a retrospective study of HeartMate II (HM II) and HeartWare HVAD recipients that received therapeutic enoxaparin as \u201cbridge\u201d therapy to describe bleeding and thrombotic events and compare outcomes between devices. The primary endpoint was the incidence of bleeding within 30 days of \u201cbridge\u201d episode. Major bleeding was defined by INTERMACS criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>We evaluated 257 \u201cbridge\u201d episodes in 54 patients, 35 with a HM II device and 19 with an HVAD device that underwent 176 and 81 bridging episodes, respectively. The median INR prior to \u201cbridge\u201d was lower in the HM II group compared to the HVAD group (1.5 vs 1.7, P &lt; .01), however, there was no difference in the median duration of \u201cbridge\u201d therapy (7 vs 7 days, P = .42). There were a total of 30 (12%) bleeding episodes, with the majority in the HM II group vs HVAD (26 [15%] vs 4 [5%], P = .02). We observed 3 (1%) thromboembolic events in 2 (4%) patients with an HVAD device. On multivariate analysis, the presence of a HM II device was associated with a 4-fold increased risk of bleeding.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>We found the use of enoxaparin \u201cbridge\u201d therapy to be associated with a higher incidence of bleeding in patients with a HM II device compared with an HVAD device. Assessment of device- and patient-specific factors should be evaluated to minimize bleeding events.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10742484211006998","type":"journal-article","created":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T15:09:21Z","timestamp":1618240161000},"page":"473-479","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Comparison of Outcomes of Enoxaparin Bridge Therapy in HeartMate II versus HeartWare HVAD Recipients"],"prefix":"10.1177","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4792-015X","authenticated-orcid":false,"given":"Mitulkumar","family":"Patel","sequence":"first","affiliation":[{"name":"Department of Pharmacy, NYU Langone Health, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1833-4124","authenticated-orcid":false,"given":"Tania","family":"Ahuja","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, NYU Langone Health, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9322-1758","authenticated-orcid":false,"given":"Serena","family":"Arnouk","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, NYU Langone Health, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Gidea","sequence":"additional","affiliation":[{"name":"Department of Cardiology, NYU Langone Health, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"Reyentovich","sequence":"additional","affiliation":[{"name":"Department of Cardiology, NYU Langone Health, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"III","given":"Deane E.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, NYU Langone Health, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nader","family":"Moazami","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, NYU Langone Health, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Papadopoulos","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, NYU Langone Health, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tyler C.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, NYU Langone Health, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,4,12]]},"reference":[{"key":"bibr1-10742484211006998","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1602954"},{"key":"bibr2-10742484211006998","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2009.05.018"},{"key":"bibr3-10742484211006998","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0909938"},{"key":"bibr4-10742484211006998","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2013.12.001"},{"key":"bibr5-10742484211006998","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2015.05.011"},{"key":"bibr6-10742484211006998","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2010.01.011"},{"key":"bibr7-10742484211006998","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2016.10.001"},{"key":"bibr8-10742484211006998","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000000612"},{"key":"bibr9-10742484211006998","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2020.01.834"},{"key":"bibr10-10742484211006998","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2019.01.771"},{"key":"bibr11-10742484211006998","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2019.01.181"},{"key":"bibr12-10742484211006998","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2012.04630.x"},{"key":"bibr13-10742484211006998","volume-title":"Manual 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