{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T06:31:47Z","timestamp":1777530707198,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T00:00:00Z","timestamp":1623888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cardiovasc Pharmacol Ther"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Angiotensin-converting enzyme inhibitor (ACE-I) and angiotensin receptor blocker (ARB) discontinuation during acute heart failure (AHF) is associated with increased mortality following hospitalization. Although the etiology of acute kidney injury (AKI) in type 1 cardiorenal syndrome (CRS) has been linked to renal venous congestion, ACE-I\/ARB withdrawal (AW) theoretically promotes renal function recovery. ACE-I\/ARBs are dose-reduced or withheld in approximately half of patients with CRS, but the subsequent impact on renal function remains largely uninvestigated. This study compared AW to ACE-I\/ARB continuation (AC) during CRS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This was a retrospective, single-center chart review. Patients aged 18-89 years admitted from April 2018 to August 2019 with AHF and AKI were identified using discharge ICD-10 codes. All patients were treated with an ACE-I\/ARB before admission. Key exclusion criteria included shock, pregnancy, and end-stage renal disease. The primary endpoint was change in serum creatinine (SCr) from admission through 72 hours. Data were analyzed utilizing chi-square and Mann-Whitney U tests with SPSS software.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 111 admissions were included. AW occurred in 68 patients upon admission. AW patients presented with a higher blood urea nitrogen ( P = 0.034), higher SCr ( P = 0.021), and lower ejection fraction ( P = 0.04). Median SCr change from admission to 72 hours did not differ between groups (AW \u22120.1 mg\/dL vs AC 0.0 mg\/dL, P = 0.05). There was no difference in SCr reduction \u22650.3 mg\/dL at 72 hours, 30-day readmissions, or ACE-I\/ARB prescription at discharge.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>In patients with type 1 CRS, AW was not associated with improved renal function at 72 hours. A larger sample size is necessary to confirm these results.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10742484211022625","type":"journal-article","created":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T12:56:02Z","timestamp":1623934562000},"page":"611-618","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Impact of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers on Renal Function in Type 1 Cardiorenal Syndrome"],"prefix":"10.1177","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0778-3901","authenticated-orcid":false,"given":"Daniel T.","family":"Ilges","sequence":"first","affiliation":[{"name":"Department of Pharmacy Services, SSM Health Saint Louis University Hospital, St. Louis, MO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morgan L.","family":"Dermody","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, St. Louis College of Pharmacy at UHSP, St. Louis, MO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caitlyn","family":"Blankenship","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, St. Louis College of Pharmacy at UHSP, St. Louis, MO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerie","family":"Mansfield","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Services, SSM Health Saint Louis University Hospital, St. Louis, MO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8232-1884","authenticated-orcid":false,"given":"Joseph S.","family":"Van Tuyl","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Services, SSM Health Saint Louis University Hospital, St. Louis, MO, USA"},{"name":"Department of Pharmacy Practice, St. Louis College of Pharmacy at UHSP, St. Louis, MO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,6,17]]},"reference":[{"key":"bibr1-10742484211022625","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.01.077"},{"key":"bibr2-10742484211022625","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000664"},{"key":"bibr3-10742484211022625","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfp169"},{"key":"bibr4-10742484211022625","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp507"},{"key":"bibr5-10742484211022625","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(88)80087-0"},{"key":"bibr6-10742484211022625","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199108013250501"},{"issue":"12","key":"bibr7-10742484211022625","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1136\/heartjnl-2018-314158","volume":"105","author":"Clark 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