{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:32:41Z","timestamp":1790821961825,"version":"4.1.0"},"reference-count":64,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cardiovasc Pharmacol Ther"],"published-print":{"date-parts":[[2023,1,1]]},"abstract":"<jats:p>Fondaparinux sodium is a chemically synthesized selective factor Xa inhibitor approved for the prevention and treatment of venous thromboembolic events, that is, deep vein thrombosis, pulmonary embolism, and superficial vein thrombosis, in acutely ill (including those affected by COVID-19 or cancer patients) and those undergoing surgeries. Since its approval in 2002, the efficacy and safety of fondaparinux is well demonstrated by many clinical studies, establishing the value of fondaparinux in clinical practice. Some of the advantages with fondaparinux are its chemical nature of synthesis, minimal risk of contamination, 100% absolute bioavailability subcutaneously, instant onset of action, a long half-life, direct renal excretion, fewer adverse reactions when compared with direct oral anticoagulants, and being an ideal alternative in conditions where oral anticoagulants are not approved for use or in patients intolerant to low molecular weight heparins (LMWH). In the last decade, the real-world use of fondaparinux has been explored in other conditions such as acute coronary syndromes, bariatric surgery, in patients developing vaccine-induced immune thrombotic thrombocytopenia (VITT) and in pregnant women with heparin-induced thrombocytopenia (HIT), or those intolerant to LMWH. The emerging data from these studies have culminated in recent updates in the guidelines that recommend the use of fondaparinux under various conditions. This paper aims to review the recent data and the subsequent updates in the recommendations of various guidelines on the use of fondaparinux sodium.<\/jats:p>","DOI":"10.1177\/10742484221145010","type":"journal-article","created":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T05:01:14Z","timestamp":1672722074000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":40,"title":["Fondaparinux Sodium: Recent Advances in the Management of Thrombosis"],"prefix":"10.1177","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6192-1741","authenticated-orcid":false,"given":"Rupert M.","family":"Bauersachs","sequence":"first","affiliation":[{"name":"Department of Angiology, Cardioangiologic Center Bethanien, Frankfurt, Germany"},{"name":"Center for Vascular Research, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,1,3]]},"reference":[{"key":"bibr1-10742484221145010","unstructured":"Summary of product characteristics. 2002. Accessed December 14, 2022. https:\/\/www.ema.europa.eu\/en\/documents\/product-information\/arixtra-epar-product-information_en.pdf"},{"key":"bibr2-10742484221145010","doi-asserted-by":"publisher","DOI":"10.1111\/j.0960-135X.2005.01454.x"},{"key":"bibr3-10742484221145010","doi-asserted-by":"publisher","DOI":"10.1111\/j.1527-3466.2002.tb00081.x"},{"key":"bibr4-10742484221145010","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/9545297"},{"key":"bibr5-10742484221145010","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pmbts.2019.02.004"},{"key":"bibr6-10742484221145010","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200241002-00001"},{"key":"bibr7-10742484221145010","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200103013440901"},{"key":"bibr8-10742484221145010","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011099"},{"key":"bibr9-10742484221145010","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011100"},{"key":"bibr10-10742484221145010","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08652-X"},{"key":"bibr11-10742484221145010","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08648-8"},{"key":"bibr12-10742484221145010","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.162.16.1833"},{"key":"bibr13-10742484221145010","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.11.1337"},{"key":"bibr14-10742484221145010","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1677522"},{"key":"bibr15-10742484221145010","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2014.03.029"},{"issue":"4","key":"bibr16-10742484221145010","first-page":"448","volume":"34","author":"Zhang F","year":"2014","journal-title":"Nan Fang Yi Ke Da Xue Bao"},{"key":"bibr17-10742484221145010","doi-asserted-by":"publisher","DOI":"10.1111\/jth.15358"},{"key":"bibr18-10742484221145010","unstructured":"Food and Drug Administration. 2001. Accessed December 14, 2022. https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/nda\/2001\/21-345_Arixtra_Approv.pdf"},{"key":"bibr19-10742484221145010","unstructured":"European Medicines Agency. 2010. Accessed December 14, 2022. https:\/\/www.ema.europa.eu\/en\/documents\/overview\/arixtra-epar-summary-public_en.pdf"},{"key":"bibr20-10742484221145010","doi-asserted-by":"publisher","DOI":"10.1093\/ajhp\/58.suppl_2.S14"},{"key":"bibr21-10742484221145010","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.162.16.1833"},{"key":"bibr22-10742484221145010","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa035451"},{"key":"bibr23-10742484221145010","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-140-11-200406010-00007"},{"key":"bibr24-10742484221145010","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.5154"},{"key":"bibr25-10742484221145010","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38733.466748.7C"},{"key":"bibr26-10742484221145010","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.13.joc60038"},{"key":"bibr27-10742484221145010","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa055443"},{"key":"bibr28-10742484221145010","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn358"},{"key":"bibr29-10742484221145010","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0912072"},{"key":"bibr30-10742484221145010","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-152-4-201002160-00006"},{"key":"bibr31-10742484221145010","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0b013e328349a9e3"},{"key":"bibr32-10742484221145010","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2017.07.009"},{"key":"bibr33-10742484221145010","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2021.04.015"},{"key":"bibr34-10742484221145010","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmv.2010.05.004"},{"key":"bibr35-10742484221145010","unstructured":"Sindhu S, Silberstein P. Vascular Medicine: A Companion to Braunwald\u2019s Heart Disease . 2nd ed. 2013. Accessed December 14, 2022. https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/fondaparinux"},{"key":"bibr36-10742484221145010","doi-asserted-by":"publisher","DOI":"10.1177\/2192568219852051"},{"key":"bibr37-10742484221145010","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2018.33.e213"},{"key":"bibr38-10742484221145010","first-page":"14","author":"Villines TC","year":"2020","journal-title":"Clin Med Insights Cardiol"},{"key":"bibr39-10742484221145010","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26165004"},{"key":"bibr40-10742484221145010","doi-asserted-by":"publisher","DOI":"10.1111\/jth.15341"},{"key":"bibr41-10742484221145010","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2104840"},{"key":"bibr42-10742484221145010","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17613"},{"key":"bibr43-10742484221145010","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2021.02.081"},{"issue":"1","key":"bibr44-10742484221145010","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ciresp.2020.11.008","volume":"100","author":"Calzada M","year":"2022","journal-title":"Cir Esp (Engl Ed)"},{"key":"bibr45-10742484221145010","doi-asserted-by":"publisher","DOI":"10.1016\/j.soard.2014.10.003"},{"key":"bibr46-10742484221145010","doi-asserted-by":"publisher","DOI":"10.1177\/10760296211014575"},{"key":"bibr47-10742484221145010","first-page":"461","volume":"11","author":"Bartlett MA","year":"2015","journal-title":"Vasc Health Risk Manag"},{"key":"bibr48-10742484221145010","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0912072"},{"key":"bibr49-10742484221145010","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-016-1354-3"},{"key":"bibr50-10742484221145010","doi-asserted-by":"publisher","DOI":"10.1002\/rth2.12169"},{"key":"bibr51-10742484221145010","doi-asserted-by":"publisher","DOI":"10.1002\/rth2.12145"},{"key":"bibr52-10742484221145010","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2018024802"},{"key":"bibr53-10742484221145010","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2018022954"},{"key":"bibr54-10742484221145010","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020003442"},{"key":"bibr55-10742484221145010","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa575"},{"key":"bibr56-10742484221145010","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2020.09.023"},{"issue":"10","key":"bibr57-10742484221145010","first-page":"1181","volume":"19","author":"Streiff MB","year":"2021","journal-title":"J Natl Compr Canc Netw"},{"key":"bibr58-10742484221145010","unstructured":"World Health Organization report. COVID-19 clinical management living guidance. Published January 25, 2021. Accessed December 14, 2022. https:\/\/apps.who.int\/iris\/handle\/10665\/338882"},{"key":"bibr59-10742484221145010","doi-asserted-by":"publisher","DOI":"10.1177\/00368504211025927"},{"key":"bibr60-10742484221145010","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0207410"},{"key":"bibr61-10742484221145010","doi-asserted-by":"publisher","DOI":"10.2165\/00129784-200505020-00006"},{"key":"bibr62-10742484221145010","doi-asserted-by":"publisher","DOI":"10.2165\/11589290-000000000-00000"},{"key":"bibr63-10742484221145010","doi-asserted-by":"publisher","DOI":"10.1007\/s10198-006-0017-2"},{"issue":"4","key":"bibr64-10742484221145010","first-page":"214","volume":"4","author":"Di Benedetto P","year":"2017","journal-title":"Joints"}],"container-title":["Journal of Cardiovascular Pharmacology and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10742484221145010","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10742484221145010","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10742484221145010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:41:36Z","timestamp":1777394496000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10742484221145010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,1]]},"references-count":64,"alternative-id":["10.1177\/10742484221145010"],"URL":"https:\/\/doi.org\/10.1177\/10742484221145010","relation":{},"ISSN":["1074-2484","1940-4034"],"issn-type":[{"value":"1074-2484","type":"print"},{"value":"1940-4034","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,1]]},"article-number":"10742484221145010"}}