{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T15:40:46Z","timestamp":1779205246212,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cardiovasc Pharmacol Ther"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Metabolic syndrome (MS) is associated with abnormalities in atrial mechanics, atrial remodeling, and an increased risk of heart rhythm disorders. One of the most commonly used approaches to the prevention of cardiac remodeling in arterial hypertension is the administration of renin\u2013angiotensin system (RAS) inhibitors. Therefore, this study aimed to investigate the effects of RAS inhibitors on atrial mechanics parameters in patients with MS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and materials<\/jats:title>\n                    <jats:p>This longitudinal observational study included 55 patients with hypertension and MS, as defined by the ATP III criteria. The patients were evaluated at the start of antihypertensive treatment with an RAS inhibitor. The patients\u2019 clinical characteristics, chosen pharmacological treatment, and transthoracic echocardiography findings were recorded at baseline and 6 months thereafter. A student's dependent sample t-test was used for comparisons between groups. Pearson correlation was used to evaluate the relationships between variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Patients with MS had higher peak atrial longitudinal strain (PALS) values at 6 months than at baseline. Meanwhile, systolic strain and peak late strain rates were lower at follow-up than at baseline. The different antihypertensive treatments had comparable effects on the PALS changes during the follow-up period. Higher high-density lipoprotein levels at baseline were correlated with changes in PALS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The administration of RAS inhibitors improved atrial mechanics parameters in the early stages of antihypertensive management in MS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10742484231216807","type":"journal-article","created":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T01:10:20Z","timestamp":1701220220000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Effects of Renin\u2013Angiotensin System Inhibitors on Atrial Mechanics Parameters in Patients with Metabolic Syndrome"],"prefix":"10.1177","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4689-4404","authenticated-orcid":false,"given":"Juan A.","family":"Peraza-Zaldivar","sequence":"first","affiliation":[{"name":"Programa de Doctorado en Farmacolog\u00eda, Departamento de Fisiolog\u00eda, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan M.","family":"Ponce-Guarneros","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Mexico"},{"name":"Instituto de Terap\u00e9utica Experimental y Cl\u00ednica, Departamento de Fisiolog\u00eda, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernesto G.","family":"Cardona-Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Instituto de Terap\u00e9utica Experimental y Cl\u00ednica, Departamento de Fisiolog\u00eda, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yussef","family":"Esparza-Guerrero","sequence":"additional","affiliation":[{"name":"Programa de Doctorado en Farmacolog\u00eda, Departamento de Fisiolog\u00eda, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana M.","family":"Salda\u00f1a-Cruz","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Mexico"},{"name":"Instituto de Terap\u00e9utica Experimental y Cl\u00ednica, Departamento de Fisiolog\u00eda, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio A.","family":"Gonz\u00e1lez-Vazquez","sequence":"additional","affiliation":[{"name":"Programa de Doctorado en Farmacolog\u00eda, Departamento de Fisiolog\u00eda, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Mexico"},{"name":"Departamento de Medicina Interna-Terapia Intensiva Hospital General Region #110, Instituto Mexicano del Seguro Social, Guadalajara, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Gonzalez-Lopez","sequence":"additional","affiliation":[{"name":"Programa de Doctorado en Farmacolog\u00eda, Departamento de Fisiolog\u00eda, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Mexico"},{"name":"Instituto Regional de Investigaci\u00f3n en Salud P\u00fablica, Programa de Doctorado y Coordinaci\u00f3n del Programa de Doctorado en Salud P\u00fablica, Departamento de Salud P\u00fablica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge I.","family":"Gamez-Nava","sequence":"additional","affiliation":[{"name":"Programa de Doctorado en Farmacolog\u00eda, Departamento de Fisiolog\u00eda, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Mexico"},{"name":"Instituto Regional de Investigaci\u00f3n en Salud P\u00fablica, Programa de Doctorado y Coordinaci\u00f3n del Programa de Doctorado en Salud P\u00fablica, Departamento de Salud P\u00fablica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7643-6298","authenticated-orcid":false,"given":"Norma A.","family":"Rodriguez-Jimenez","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Mexico"},{"name":"Instituto de Terap\u00e9utica Experimental y Cl\u00ednica, Departamento de Fisiolog\u00eda, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,11,28]]},"reference":[{"key":"bibr1-10742484231216807","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.192644"},{"key":"bibr2-10742484231216807","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2018.10.003"},{"key":"bibr3-10742484231216807","doi-asserted-by":"publisher","DOI":"10.5114\/aoms\/152921"},{"key":"bibr4-10742484231216807","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.539528"},{"key":"bibr5-10742484231216807","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2015.76"},{"key":"bibr6-10742484231216807","doi-asserted-by":"publisher","DOI":"10.1159\/000368754"},{"key":"bibr7-10742484231216807","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00937.2006"},{"key":"bibr8-10742484231216807","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2010.4"},{"key":"bibr9-10742484231216807","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.30.13"},{"key":"bibr10-10742484231216807","doi-asserted-by":"publisher","DOI":"10.1161\/circ.106.25.3143"},{"key":"bibr11-10742484231216807","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jey018"},{"key":"bibr12-10742484231216807","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.01.059"},{"key":"bibr13-10742484231216807","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.115.004229"},{"issue":"3","key":"bibr14-10742484231216807","first-page":"49","volume":"34","author":"Americo 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