{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T06:21:15Z","timestamp":1777530075357,"version":"3.51.4"},"reference-count":37,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003669","name":"Korea Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["2016-ER6304-02"],"award-info":[{"award-number":["2016-ER6304-02"]}],"id":[{"id":"10.13039\/501100003669","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cardiovasc Pharmacol Ther"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study evaluates the 3-year clinical outcomes of high Killip grade (III\/IV) acute myocardial infarction (AMI) patients treated with either \u03b2-blockers (BB) and angiotensin-converting enzyme inhibitors (ACEI) or BB and angiotensin receptor blockers (ARB).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 13,105 patients were registered at the Korea Acute Myocardial Infarction Registry at the National Institute of Health (KAMIR-NIH). Among them, 871 patients with high Killip classification AMI were divided into the BB\u2009+\u2009ACEI group (n\u2009=\u2009489) and the BB\u2009+\u2009ARB group (n\u2009=\u2009381). Following propensity score matching, 343 patients were selected in each group. All patients completed a 3-year follow-up period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The results indicate no significant differences between the BB\u2009+\u2009ACEI group and BB\u2009+\u2009ARB group in terms of cardiac death, recurrent myocardial infarction, and the rate of repeat percutaneous coronary intervention. However, the BB\u2009+\u2009ACEI group exhibited significantly lower risks in major adverse cardiac events (HR\u2009=\u20090.574, 95% CI: 0.421\u20130.783, p\u2009&lt;\u2009.001), all-cause mortality (HR\u2009=\u20090.561, 95% CI: 0.404\u20130.778, p\u2009=\u2009.001), and non-cardiac death (HR\u2009=\u20090.365, 95% CI: 0.208\u20130.639, p\u2009&lt;\u2009.001) compared to the BB\u2009+\u2009ARB group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our results suggest that BB\u2009+\u2009ACEI treatment is more beneficial than BB\u2009+\u2009ARB for high Killip grade AMI patients. Additionally, the BB\u2009+\u2009ACEI group has a superior preventative effect on mortality compared to the BB\u2009+\u2009ARB group.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10742484241264673","type":"journal-article","created":{"date-parts":[[2024,7,21]],"date-time":"2024-07-21T10:15:20Z","timestamp":1721556920000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Beyond \u03b2-Blockade: ACE Inhibitors Reduce Non-Cardiac Mortality in High Killip Grade AMI Patients"],"prefix":"10.1177","volume":"29","author":[{"given":"Simei","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Zhoushan Hospital, Wenzhou Medical University, Zhoushan, China"},{"name":"Department of Cardiology, Chonnam National University Hospital, Gwangju, 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Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4495-9622","authenticated-orcid":false,"given":"Cheng","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic, Zhoushan Hospital, Wenzhou Medical University, Zhoushan, 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