{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T23:23:31Z","timestamp":1790205811890,"version":"4.1.0"},"reference-count":29,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008092","name":"Jinhua Science and Technology Bureau","doi-asserted-by":"publisher","award":["2023-3-068"],"award-info":[{"award-number":["2023-3-068"]}],"id":[{"id":"10.13039\/501100008092","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cardiovasc Pharmacol Ther"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>Background and Objectives: The efficacy and safety of a lower target dose of sacubitril\/valsartan (angiotensin receptor neprilysin inhibitor [ARNI]) for treating heart failure with reduced ejection fraction (HFrEF) in Chinese patients with moderate-to-severe chronic kidney disease (CKD) remain unknown. We performed a retrospective study to compare the efficacy of ARNI with that of angiotensin-converting enzyme inhibitors (ACEIs)\/angiotensin receptor blockers (ARBs) in patients with HFrEF and moderate-to-severe CKD. Methods: This retrospective study included 129 patients. An inverse probability of treatment weighting (IPTW) analysis was performed to compare the baseline characteristics and outcomes between the 2 groups. The incidence of death due to cardiovascular disease, rehospitalization due to heart failure after treatment, and improvement in cardiac function symptoms (New York Heart Association [NYHA]) were assessed after 12 months. Improvements of ejection fraction (EF), N-terminal pro-brain natriuretic peptide (NT-proBNP) level, left ventricular end-systolic diameter (LVESD), and left ventricular end-diastolic diameter (LVEDD) were compared. Results: Compared with the ACEI\/ARB group, the ARNI group, with 90.77% (59\/65) in the lower target dose group, showed a lower rate of death due to cardiovascular disease (6.6% vs 0.9% after IPTW) and a lower incidence of rehospitalization (46.5% vs 30.4% after IPTW). NYHA class, estimated glomerular filtration rate, EF, NT-ProBNP levels, LVEDD, and LVESD improved in the ARNI group. None of the patients withdrew from treatment because of adverse drug reactions. Conclusion: Our study showed that ARNI resulted in a greater improvement in heart failure than ACEIs\/ARBs in patients with HFrEF and moderate-to-severe CKD.<\/jats:p>","DOI":"10.1177\/10742484241265337","type":"journal-article","created":{"date-parts":[[2024,7,21]],"date-time":"2024-07-21T10:16:50Z","timestamp":1721557010000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Comparison of the Efficacy and Safety of Sacubitril\/Valsartan and Angiotensin-Converting Enzyme Inhibitors\/Angiotensin Receptor Blockers in Patients With Reduced Ejection Fraction Combined With Moderate-to-Severe Chronic Kidney Disease"],"prefix":"10.1177","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-6121-3522","authenticated-orcid":false,"given":"Zhaowei","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenjue","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The Third Hospital of Changsha, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuchun","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangwen","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, 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