{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T00:35:13Z","timestamp":1778891713621,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Cardiovasc Pharmacol Ther"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>Aims: Calcium channel blockers (CCBs) are frequently co-administered with clopidogrel in cardiovascular disease. Although an inhibitory drug interaction exists between them, comprehensive large-scale studies for its validation are lacking. We investigated interactions between CCBs and clopidogrel using a large-scale national registry of patients who underwent percutaneous coronary intervention (PCI). Methods and Results: The Platelet function and genoType-Related long-term Prognosis-Platelet Function Test consortium investigates the association between platelet function test and long-term prognosis during dual antiplatelet therapy including clopidogrel in patients using drug-eluting stents. We compared the ex vivo platelet reactivity using the VerifyNow P2Y12 test and clinical outcomes between CCB users and non-users. Between 2003 and 2018, 11\u2005714 patients were enrolled and categorized into two groups according to CCB usage. A composite endpoint encompassing all-cause mortality, myocardial infarction, stent thrombosis, or stroke was defined as a major adverse cardiac and cerebrovascular event (MACCE). During the 5-year follow-up period, no significant differences were observed in P2Y12 reaction units (215.8\u2009\u00b1\u200984.7 vs 218.4\u2009\u00b1\u200976.7, P\u2009=\u2009.156), MACCEs, major bleeding, or high platelet reactivity rates, even after adjusting for propensity score matching (PSM) and inverse probability of treatment weighting (IPTW). When limited to the high platelet reactivity cohort (\u2265252\u2005PRU), the results remained consistent for MACCE [PSM-adjusted, HR: 0.923 (0.644-1.323), P-value .663; IPTW-adjusted, HR: 1.300 (0.822-2.056), P-value .262]. Conclusions: CCB and clopidogrel co-administration does not appear to significantly impact clopidogrel responsiveness or clinical outcomes. Despite these promising results, further investigation may be warranted. Clinical trial registration: Platelet Function and genoType-Related Long-term progGosis in DES-treated Patients: A Consortium From Multi-centered Registries [PTRG-DES]; NCT04734028<\/jats:p>","DOI":"10.1177\/10742484241298150","type":"journal-article","created":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T05:43:33Z","timestamp":1731908613000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Effect of Calcium Channel Blockers on Antiplatelet Activity of Clopidogrel in Patients Undergoing Percutaneous Coronary Intervention: Insights from the PTRG-DES Consortium"],"prefix":"10.1177","volume":"29","author":[{"given":"HoungBeom","family":"Ahn","sequence":"first","affiliation":[{"name":"Department of Cardiology, Cardiovascular Center, Seoul National University Bundang Hospital, Seongnam, South Korea"},{"name":"Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South 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University School of Medicine, Changwon, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Gyun","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Yonsei University Wonju Severance Christian Hospital, Wonju, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Yeup","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, South Korea"},{"name":"Division of Cardiology, Chung-Ang University Gwangmyeong Hospital, Gwangmyeong, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Rae","family":"Cho","sequence":"additional","affiliation":[{"name":"Cardiology Division, Department of Internal Medicine, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyo-Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Cardiovascular Center, Seoul National University Hospital, Seoul, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moo Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Dong-A University Hospital, Busan, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Do-Sun","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Center, Korea University Anam Hospital, Korea University College of Medicine, Seoul, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun-Seok","family":"Shin","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, South 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