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Sirt1-AS, a lncRNA, has been shown to play a role in cardiovascular diseases. This study aimed to explore the role of Sirt1-AS in cardiac hypertrophy and the underlying molecular mechanism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A mouse model of pressure-overload cardiac hypertrophy was established via transverse aortic constriction (TAC). Cardiac tissues of TAC mice and cardiomyocytes treated with angiotensin II (AngII) were examined for Sirt1-AS and Sirt1 expression levels. The effects of Sirt1-AS overexpression or knockdown on cardiomyocyte size and hypertrophic marker expression were accessed. Furthermore, the molecular interaction between Sirt1-AS and Sirt1 were investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sirt1-AS expression was found to be downregulated in the hearts of TAC mice and in Ang II-treated cardiomyocytes. Overexpression of Sirt1-AS attenuated cardiac hypertrophy, while its suppression exacerbated the hypertrophic response. Mechanistic studies demonstrated that Sirt1-AS directly influenced Sirt1 mRNA and protein expression levels. Moreover, the protective effects of Sirt1-AS against cardiac hypertrophy were abolished upon Sirt1 mRNA inhibition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings suggest that Sirt1-AS exerts a protective effect against cardiac hypertrophy by modulating Sirt1 expression. This research provides novel insights into the role of lncRNAs in cardiac hypertrophy and highlights Sirt1-AS as a potential therapeutic target for the treatment of cardiac hypertrophy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10742484251356358","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T12:55:24Z","timestamp":1756472124000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["LncRNA Sirt1-AS Protects Against Cardiac Hypertrophy by Modulating Sirt1"],"prefix":"10.1177","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-6802-0756","authenticated-orcid":false,"given":"Xuejiao","family":"Wei","sequence":"first","affiliation":[{"name":"Guizhou University Medical College, Guiyang, Guizhou, PR China"},{"name":"Guizhou Educational University Biological College, Guiyang, Guizhou, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1887-584X","authenticated-orcid":false,"given":"Chenrui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Guizhou University Medical College, Guiyang, Guizhou, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7166-2358","authenticated-orcid":false,"given":"Shuanglong","family":"Mou","sequence":"additional","affiliation":[{"name":"Guizhou University Medical College, Guiyang, Guizhou, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqin","family":"He","sequence":"additional","affiliation":[{"name":"Guizhou University Medical College, Guiyang, Guizhou, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyun","family":"Si","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Li","sequence":"additional","affiliation":[{"name":"Guizhou University Medical College, Guiyang, Guizhou, PR 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