{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T06:17:07Z","timestamp":1777529827548,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[1999,3,1]],"date-time":"1999-03-01T00:00:00Z","timestamp":920246400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cardiovasc Pharmacol Ther"],"published-print":{"date-parts":[[1999,3]]},"abstract":"<jats:p>\n                    Background: Intravenous amiodarone has increasingly been used to control life-threaten ing atrial and ventricular arrhythmias. In addition to its four antiarrhythmic properties, amio darone may have complex effects on intracellular Ca\n                    <jats:sup>2+<\/jats:sup>\n                    stores and myocyte contractility.\n                  <\/jats:p>\n                  <jats:p>\n                    Methods and Results: Contraction amplitude was recorded for cardiac ventricular myo cytes isolated from neonatal and adult rabbits. Sarcoplasmic reticulum (SR) Ca\n                    <jats:sup>2+<\/jats:sup>\n                    stores were loaded to steady-state levels by a train of eight electric field stimulations. The SR Ca\n                    <jats:sup>2+<\/jats:sup>\n                    load was quantified by recording the contraction amplitude resulting from the complete depletion of SR Ca\n                    <jats:sup>2+<\/jats:sup>\n                    stores by exposing the cell to a 1-second pulse of 10 mmol\/L caffeine. After the cells were exposed to 1 \u03bcmol\/L amiodarone for 10 minutes, electrically stimulated contraction amplitudes significantly decreased in both adult and neonatal cells. Caffeine- induced cell contraction amplitudes were not affected by amiodarone in adult ventricular myocytes. By contrast, amiodarone markedly inhibited caffeine-induced contractions in neonatal ventricular myocytes. The inhibitory effect of amiodarone on the caffeine-induced contractions was not replicated by Ca\n                    <jats:sup>2+<\/jats:sup>\n                    channel blockade with diltiazem.\n                  <\/jats:p>\n                  <jats:p>\n                    Conclusions: Amiodarone markedly inhibits caffeine-induced contraction in neonatal myo cytes but has no significant effect on adult myocytes. Ca\n                    <jats:sup>2+<\/jats:sup>\n                    influx through amiodarone-sensitive Ca\n                    <jats:sup>2+<\/jats:sup>\n                    channels may play a primary role in maintaining SR Ca\n                    <jats:sup>2+<\/jats:sup>\n                    stores in neonatal heart.\n                  <\/jats:p>","DOI":"10.1177\/107424849900400105","type":"journal-article","created":{"date-parts":[[2007,11,26]],"date-time":"2007-11-26T17:52:29Z","timestamp":1196099549000},"page":"23-32","source":"Crossref","is-referenced-by-count":0,"title":["Age-Dependent Changes in the Effects of Amiodarone on Rabbit Cardiac Myocyte Contractions"],"prefix":"10.1177","volume":"4","author":[{"family":"Fuhua Chen","sequence":"first","affiliation":[{"name":"University of California at Los Angeles, School of Medicine, Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suhaila","family":"Naim","sequence":"additional","affiliation":[{"name":"University of California at Los Angeles, School of Medicine, Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William F.","family":"Friedman","sequence":"additional","affiliation":[{"name":"University of California at Los Angeles, School of Medicine, Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas S.","family":"Klitzner","sequence":"additional","affiliation":[{"name":"University of California at Los Angeles, School of Medicine, Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glenn T.","family":"Wetzel","sequence":"additional","affiliation":[{"name":"University of California at Los Angeles, School of Medicine, Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1999,3,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.4960200706"},{"key":"atypb2","doi-asserted-by":"crossref","first-page":"56S","DOI":"10.1002\/j.1875-9114.1997.tb03735.x","volume":"17","author":"Singh BN","year":"1997","journal-title":"Pharmacotherapy"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(97)00069-7"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(95)00591-9"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1159\/000457473"},{"key":"atypb6","first-page":"583","volume":"44","author":"Chen F.","year":"1996","journal-title":"J Invest 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