{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:04:32Z","timestamp":1777478672957,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2002,7,1]],"date-time":"2002-07-01T00:00:00Z","timestamp":1025481600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2002,7]]},"abstract":"<jats:p>During an 18-month period, 10 consecutive Mexican mestizos with a clinical marker associated with a primary hypercoagulable state were studied. The assessment of the sticky platelet syndrome (SPS) was done by the method described by Mammen. In addition, the activated protein C resistance phenotype, coagulation protein C activity and antigen, coagulation protein S, antithrombin III, plasminogen, tissue-type plasminogen activator activity, plasminogen activator inhibitor activity, plasminogen activator inhibitor type 1, IgG and IgM isotypes of anti-phospholipid antibodies, homocysteine levels, the factor V gene Leiden mutation, the 677 C-&gt;T mutation in the 5,10-methylen-tetrahydrofolate-reductase (MTHFR), and the G20210A polymorphism in the 3\u2032-untranslated region of the prothrombin gene were studied. Six patients with the SPS were identified: only one displayed this as the single thrombophilic abnormality; in five others, additional thrombosis-prone conditions were found: heterozygosity for the MTHFR 677 gene mutation in five cases; and, in one case each, heterozygosity for the factor V Leiden mutation, heterozygosity for the factor II G20210A mutation, and antiphospholipid antibodies in another. Four of the six patients had a family history of thrombophilia. All patients were treated with aspirin and no new vasoocclusive episodes have been recorded. SPS in not an infrequent finding in Mexican mestizo thrombophilic patients and may contribute to thrombophilia.<\/jats:p>","DOI":"10.1177\/107602960200800312","type":"journal-article","created":{"date-parts":[[2007,6,21]],"date-time":"2007-06-21T21:15:00Z","timestamp":1182460500000},"page":"273-277","source":"Crossref","is-referenced-by-count":18,"title":["Primary Thrombophilia in Mexico III: A Prospective Study of the Sticky Platelet Syndrome"],"prefix":"10.1177","volume":"8","author":[{"given":"Guillermo J.","family":"Ruiz-Arg\u00faelles","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Briceida","family":"L\u00f3pez-Martinez","sequence":"additional","affiliation":[{"name":"Centro de Hematolog\u00eda y Medicina Interna de Puebla, Puebla, Mexico; Laboratorios Cl\u00ednicos de Puebla, Puebla, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donaj\u00ed","family":"Cruz-Cruz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luc\u00eda","family":"Esparza-Silva","sequence":"additional","affiliation":[{"name":"Laboratorios Cl\u00ednicos de Puebla, Puebla, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma. Bel\u00e9n","family":"Reyes-Aulis","sequence":"additional","affiliation":[{"name":"Universidad Aut\u00f3noma de Puebla, Puebla, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2002,7,1]]},"reference":[{"key":"atypb1","volume-title":"Ninth International Joint Conference on Stroke and Cerebral Circulation","author":"Holiday PL"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1177\/107602969800400201"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1177\/107602969500100111"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-994939"},{"key":"atypb5","doi-asserted-by":"crossref","unstructured":"5. Ruiz-Arg\u00fcelles GJ, Gonza\u00e9lez-Estrada S, Garc\u00e9s-Eisele J, et al. Primary thrombophilia in M\u00e9xico: A prospective study. Am J Hematol 1999;60:1-1.","DOI":"10.1002\/(SICI)1096-8652(199901)60:1<1::AID-AJH1>3.3.CO;2-H"},{"key":"atypb6","doi-asserted-by":"crossref","unstructured":"6. Ruiz-Arg\u00fcelles GJ, Garc\u00e9s-Eisele J, Reyes-N\u00fc\u00f1ez V, et al. Primary thrombophilia in M\u00e9xico II: Factor V G1691A (Leiden), prothrombin G20210A and methylenetetrahydrofolate reductase C677T polymorphism in thrombophilic Mexican mestizos. Am J Hematol 2001;66:28-28.","DOI":"10.1002\/1096-8652(200101)66:1<28::AID-AJH1003>3.3.CO;2-V"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1963.sp007185"},{"key":"atypb8","doi-asserted-by":"crossref","unstructured":"8. Z\u00f6ller B, Dahlb\u00e4ck B. Linkage between inherited resistance to activated protein C and factor V gene mutation in venous thrombosis. Lancet 1994;343:1536-1536.","DOI":"10.1016\/S0140-6736(94)92940-8"},{"key":"atypb9","first-page":"35","volume":"58","author":"Kluijtmans LAJ","year":"1996","journal-title":"Am J Hum Genet"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V88.10.3698.bloodjournal88103698"},{"key":"atypb11","unstructured":"11. 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