{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:10:20Z","timestamp":1777479020783,"version":"3.51.4"},"reference-count":64,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2004,7,1]],"date-time":"2004-07-01T00:00:00Z","timestamp":1088640000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2004,7]]},"abstract":"<jats:p>\n                    After the discovery of activated protein C resistance (APCR) due to factor V Leiden mutation and the causal relationship of the phenomenon with clinical thromboembolism, a wide variety of functional clotting-based assays were developed for testing of APCR in relation to the specific DNA-based analysis of FV:Q\n                    <jats:sup>506<\/jats:sup>\n                    Leiden. The aim of this study is to assess a clotting-based APCR assay using procoagulant crotalidae snake venom with respect to the sensitivity, specificity, and predictability for the presence of the factor V Leiden mutation. APCR testing and factor V DNA analyses have been performed concurrently on 319 patient specimens. APCR values of the patients with homozygous factor V Leiden mutation (70.4\u00b113.5 s) were significantly lower (p&lt;0.001) in comparison to the subjects with the heterozygous mutation (87.6\u00b113.4 s). The assay is highly sensitive (98.7%) and specific (91.9%) for the screening of factor V Leiden mutation. The sensitivity and specificity of the APCR testing reached to 100% below the cut-off value of 120 s among the patients with homozygous factor V Leiden mutation. Therefore, this method could help the desired effective optimal screening strategy for the laboratory search of hereditary thrombophilia focusing on the diagnosis of APCR due to FV:Q\n                    <jats:sup>506<\/jats:sup>\n                    .\n                  <\/jats:p>","DOI":"10.1177\/107602960401000309","type":"journal-article","created":{"date-parts":[[2006,3,31]],"date-time":"2006-03-31T17:34:07Z","timestamp":1143826447000},"page":"265-270","source":"Crossref","is-referenced-by-count":12,"title":["The Predictability of Factor V Leiden (FV:Q506) Gene Mutation via Clotting-Based Diagnosis of Activated Protein C Resistance"],"prefix":"10.1177","volume":"10","author":[{"given":"N.","family":"Say\u0131nalp","sequence":"first","affiliation":[{"name":"Hacettepe University Medical School, Department of Hematology, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. 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