{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:10:57Z","timestamp":1777479057687,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2004,10,1]],"date-time":"2004-10-01T00:00:00Z","timestamp":1096588800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2004,10]]},"abstract":"<jats:p>Endothelial injury is prevalent in patients with chronic renal failure (CRF) and may be exacerbated by commonly used intravenous (IV) iron therapy. The effects of high-dose IV iron sucrose treatment (200 mg daily in 250 mL of 0.9% saline, administered over 1 hour, median treatment duration 5 days) on circulating endothelium and\/or tissue injury markers such as hepatocyte growth factor, thrombomodulin, von Willebrand factor, and C-reactive protein levels were studied. The markers were determined in 24 anemic (mean hemoglobin 9.48 g\/dL) pre-dialysis (median creatinine clearance 21.5 mL\/min) patients with CRF and defined absolute and\/or functional iron deficiency. The measurements were performed before iron administration and 24 hours after the last infusion. All the markers remained unchanged following the IV iron therapy (all p &lt; 0.172); no thrombotic or other adverse effects were observed. In conclusion, the above high-dose IV iron sucrose supplementation does not cause evident endothelial or other tissue injury in patients with CRF, and is clinically safe.<\/jats:p>","DOI":"10.1177\/107602960401000416","type":"journal-article","created":{"date-parts":[[2006,3,31]],"date-time":"2006-03-31T17:34:07Z","timestamp":1143826447000},"page":"403-406","source":"Crossref","is-referenced-by-count":5,"title":["Endothelial Injury Markers With High-dose IntravenousIron Therapy in Renal Failure"],"prefix":"10.1177","volume":"10","author":[{"given":"Jacek","family":"Borawski","sequence":"first","affiliation":[{"name":"Department of Nephrology and Transplantology with Dialysis Unit, Medical University, Bialystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Gozdzikiewicz","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Transplantology with Dialysis Unit, Medical University, Bialystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pawel","family":"Abramowicz","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Transplantology with Dialysis Unit, Medical University, Bialystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beata","family":"Naumnik","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Transplantology with Dialysis Unit, Medical University, Bialystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michal","family":"Mysliwiec","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Transplantology with Dialysis Unit, Medical University, Bialystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2004,10,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1159\/000063552"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2003.50091"},{"issue":"1","key":"atypb3","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/S0272-6386(01)70008-X","volume":"37","author":"National Kidney Foundation","year":"2001","journal-title":"Am J Kidney Dis"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1159\/000066793"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2002.33917"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000066910.02844.D0"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2362.2002.0320s1009.x"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2002.36853"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-8981(02)00302-9"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2003.00307.x"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1097\/00001721-200010000-00006"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2002.37033"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/14.11.2680"},{"key":"atypb14","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1681\/ASN.V113539","volume":"11","author":"Roob JM","year":"2000","journal-title":"J Am Soc Nephrol"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(01)80124-4"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfg031"}],"container-title":["Clinical and Applied Thrombosis\/Hemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/107602960401000416","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/107602960401000416","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:04:43Z","timestamp":1777385083000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/107602960401000416"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,10]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2004,10]]}},"alternative-id":["10.1177\/107602960401000416"],"URL":"https:\/\/doi.org\/10.1177\/107602960401000416","relation":{},"ISSN":["1076-0296","1938-2723"],"issn-type":[{"value":"1076-0296","type":"print"},{"value":"1938-2723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,10]]}}}