{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T22:17:15Z","timestamp":1790201835861,"version":"4.1.0"},"reference-count":26,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2005,4,1]],"date-time":"2005-04-01T00:00:00Z","timestamp":1112313600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2005,4]]},"abstract":"<jats:p>Many practitioners consider low-molecular-weight heparin (LMWH) an alternative to unfractionated heparin, although there are limited safety data regarding maternal and fetal outcomes in patients using an LMWH during pregnancy. A retrospective chart review was performed on 72 patients with thrombophilia exposed to the LMWH, enoxaparin, during pregnancy. Eighty-five pregnancies resulted in 93 of 99 potential live births. Eleven of 12 twin pregnancies and one triplet pregnancy were successful. One preterm live birth infant of 33 weeks\u2019 gestation did not survive. Three patients with thrombophilia spontaneously aborted. A patient receiving injectable fertility treatment had spontaneously aborted one twin at 5 weeks\u2019 gestation. One patient terminated the pregnancy after discovering the presence of Down\u2019s syndrome. The mean maximum dose required to achieve a therapeutic anti-Xa level of 0.2-0.4 IU\/mL at 5 to 6 hours following administration, was 38.1 mg every 12 hours (median 35 mg, range 30-75 mg every 12 hours). The mean anti-Xa level was 0.28 IU\/mL (median 0.3, range 0.05-0.8 IU\/mL). A total of nine patients experienced bleeding events, two requiring discontinuation of enoxaparin for the remainder of the pregnancy. Two patients experienced injection site reactions requiring discontinuation of enoxaparin. Three patients developed preeclampsia, two placenta abruptio, and one placenta previa. No thromboembolic complications or osteoporotic fractures had occurred. Enoxaparin was safe and effective for preventing thromboembolism and adverse obstetrical complications in our patients, including 12 of 13 multiple gestation pregnancies.<\/jats:p>","DOI":"10.1177\/107602960501100206","type":"journal-article","created":{"date-parts":[[2006,3,31]],"date-time":"2006-03-31T17:34:07Z","timestamp":1143826447000},"page":"171-181","source":"Crossref","is-referenced-by-count":17,"title":["A Protocol for the Use of Enoxaparin During Pregnancy: Results from 85 Pregnancies Including 13 Multiple Gestation Pregnancies"],"prefix":"10.1177","volume":"11","author":[{"given":"Lindsay M.","family":"Huxtable","sequence":"first","affiliation":[{"name":"Midwestern University College of Pharmacy-Glendale, Department of Pharmacy Practice"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad J.","family":"Tafreshi","sequence":"additional","affiliation":[{"name":"Midwestern University College of Pharmacy-Glendale, Department of Pharmacy Practice"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon M.","family":"Ondreyco","sequence":"additional","affiliation":[{"name":"Palo Verde Hematology, Oncology, Ltd, Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2005,4,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1067\/mog.2001.116890"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8588(05)70174-X"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1989.00390100059015"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1647659"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(96)00072-1"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1016\/0029-7844(95)00452-1"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(97)70403-4"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1655903"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(99)00110-3"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2000.tb11110.x"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(00)00202-2"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1616739"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1646338"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1615890"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-857X(05)70226-X"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)92633-6"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1378\/chest.119.1_suppl.122S"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(02)00239-7"},{"key":"atypb19","unstructured":"Data on File.\n                      Aventis Pharmaceuticals."},{"key":"atypb20","unstructured":"Anticoagulation in Prosthetic Valves and Pregnancy Consensus Report (APPCR) Panel and Scientific Roundtable. Anticoagulation and enoxaparin use in patients with prosthetic heart valves and\/or pregnancy. Topol EJ, Chairman.\n                      Clin Cardiol Consensus Rep\n                      October 1, 2002:1-20."},{"key":"atypb21","unstructured":"National Osteoporosis Foundation. Physician\u2019s guide to prevention and treatment of osteoporosis.\n                      Excerpta Medica, Inc.\n                      1999. Available at: http:\/\/guideline. gov\/FRAMESETS\/guideline_fs.asp?view=full_summary& guideline=001377&sSearch_string=osteoporosis. Accessed May 5, 2003."},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1653781"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1614550"},{"key":"atypb24","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(99)70091-8"},{"key":"atypb25","doi-asserted-by":"publisher","DOI":"10.1159\/000040922"},{"key":"atypb26","unstructured":"Lovenox\n                      \u00ae\n                      Prescribing Information.\n                      Aventis Pharmaceuticals.\n                      2003."}],"container-title":["Clinical and Applied Thrombosis\/Hemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/107602960501100206","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/107602960501100206","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:04:48Z","timestamp":1777385088000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/107602960501100206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,4]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,4]]}},"alternative-id":["10.1177\/107602960501100206"],"URL":"https:\/\/doi.org\/10.1177\/107602960501100206","relation":{},"ISSN":["1076-0296","1938-2723"],"issn-type":[{"value":"1076-0296","type":"print"},{"value":"1938-2723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,4]]}}}