{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:12:54Z","timestamp":1777479174122,"version":"3.51.4"},"reference-count":8,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:p>\n                    Increase platelet count or thrombocytosis, defined as a platelet count greater than or equal to 350 \u00d7 10\n                    <jats:sup>9<\/jats:sup>\n                    \/L, is a common hematologic aberration seen in complete blood cell count. Several etiologies are documented for thrombocytosis. Extreme thrombocytosis, defined as a platelet count greater than or equal to 1,000 \u00d7 10\n                    <jats:sup>9<\/jats:sup>\n                    \/L, is rarely seen in general practice. There are limited data on the etiology of this abnormality. Here, a retrospective investigation for the etiology of severe thrombocytosis was performed. Of the 3 included reports, 535 cases with extreme thrombocytosis were investigated for their etiologies. The 2 defined etiologies are secondary thrombocytosis (66.6%) and clonal thrombocytosis. Of those cases with clonal thrombocytosis, 93.8% had myeloproliferative disorders, and 6.2% had essential thrombocytosis. Concerning bleeding and vaso-occlusive complications, all cases had these complications. In this study, 7.9% of the cases with secondary thrombocytosis experienced bleeding and vaso-occlusive complications, while 17.1% of the cases with clonal thrombocytosis did.\n                  <\/jats:p>","DOI":"10.1177\/107602960601200113","type":"journal-article","created":{"date-parts":[[2006,3,31]],"date-time":"2006-03-31T17:34:07Z","timestamp":1143826447000},"page":"85-87","source":"Crossref","is-referenced-by-count":20,"title":["Extreme Thrombocytosis: What Are the Etiologies?"],"prefix":"10.1177","volume":"12","author":[{"given":"Viroj","family":"Wiwanitkit","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2006,1,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-199101000-00013"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1054\/blre.2001.0162"},{"key":"atypb3","first-page":"68","volume":"113","author":"Schafer AI","year":"2002","journal-title":"Trans Am Clin Climatol Assoc"},{"issue":"1","key":"atypb4","first-page":"S95","volume":"83","author":"Chuncharunee S","year":"2000","journal-title":"J Med Assoc Thai"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830200408"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(94)90150-3"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200208000-00017"},{"key":"atypb8","first-page":"475","volume":"115","author":"Buss DH","year":"1991","journal-title":"Arch Pathol Lab Med"}],"container-title":["Clinical and Applied Thrombosis\/Hemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/107602960601200113","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/107602960601200113","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:05:02Z","timestamp":1777385102000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/107602960601200113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1]]},"references-count":8,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["10.1177\/107602960601200113"],"URL":"https:\/\/doi.org\/10.1177\/107602960601200113","relation":{},"ISSN":["1076-0296","1938-2723"],"issn-type":[{"value":"1076-0296","type":"print"},{"value":"1938-2723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,1]]}}}