{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T21:36:23Z","timestamp":1791149783068,"version":"4.1.0"},"reference-count":35,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2006,4,1]],"date-time":"2006-04-01T00:00:00Z","timestamp":1143849600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:p>\n                    The aim of this study was to investigate the clinical efficacy of oral Pycnogenol\u00ae (Horphag Research Ltd., UK) in patients with severe chronic venous insufficiency (CVI) in comparison to the combination of diosmin and hesperidin (Daflon\u00ae, Servier, France). A group of 86 patients with severe chronic venous insufficiency (CVI), venous hypertension, ankle swelling) and previous history of venous ulcerations received either oral Pycnogenol (capsules) 150 mg or 300 mg daily for 8 weeks or Daflon, 1000 mg\/day. All patients completed the study without dropouts. At the end of the study, microcirculatory results indicated: a progressive decrease of skin flux at rest (RF); a significant decrease in capillary filtration (RAS); an improvement in the symptomatic venous score (ASLS); a reduction in edema; a significant improvement (increase) in pO\n                    <jats:sub>2<\/jats:sub>\n                    and a decrease in pCO\n                    <jats:sub>2<\/jats:sub>\n                    in the Pycnogenol group. A significant level of improvement was reached after 4 weeks of treatment in most patients (p &lt; .05) of the Pycnogenol group while clinical improvement was significant only in 6 subjects in the Daflon group. The positive effects of treatment with Pycnogenol after 8 weeks were significantly larger in comparison with the Daflon group. In conclusion, this study confirms the fast clinical efficacy of Pycnogenol in patients with chronic venous insufficiency and venous microangiopathy and its superiority\u2014considering the evaluated parameters\u2014to the combination of diosmin and hesperidin.\n                  <\/jats:p>","DOI":"10.1177\/107602960601200209","type":"journal-article","created":{"date-parts":[[2007,6,21]],"date-time":"2007-06-21T21:15:00Z","timestamp":1182460500000},"page":"205-212","source":"Crossref","is-referenced-by-count":47,"title":["Comparison of Pycnogenol\u00ae and Daflon\u00ae in Treating Chronic Venous Insufficiency: A Prospective, Controlled Study"],"prefix":"10.1177","volume":"12","author":[{"given":"M. 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Vascular Lab and Physiology, Department of Biomedical Sciences, G D\u2019Annunzio, Chieti-Pescara University, San Valentino Vascular Screening Project, Faculty of Motory Sciences, L\u2019Aquila University, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Cacchio","sequence":"additional","affiliation":[{"name":"Irvine2 Vascular Lab and Physiology, Department of Biomedical Sciences, G D\u2019Annunzio, Chieti-Pescara University, San Valentino Vascular Screening Project, Faculty of Motory Sciences, L\u2019Aquila University, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Di Renzo","sequence":"additional","affiliation":[{"name":"Irvine2 Vascular Lab and Physiology, Department of Biomedical Sciences, G D\u2019Annunzio, Chieti-Pescara University, San Valentino Vascular Screening Project, Faculty of Motory Sciences, L\u2019Aquila University, 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Efficacy of Daflon 500 on capillary filtration, laser Doppler, PO\n                      2\n                      and pCO\n                      2\n                      over a 6 months treatment period in 50 patients with CVI and edema. Protocol CL3-5682-086-ITA (data on file, unpublished)."},{"key":"atypb33","unstructured":"Informatore Farmaceutico, Edimed, OEMF, Milan 2001."},{"key":"atypb34","unstructured":"Belcaro G. Venous hypertensive microangiopathy: evaluation with laser Doppler flowmetry. PhD Thesis. 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