{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T15:47:13Z","timestamp":1777477633457,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2007,10,1]],"date-time":"2007-10-01T00:00:00Z","timestamp":1191196800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:p>Sepsis-induced systemic inflammation results in coagulation abnormalities that may be different in gram-positive and gram-negative infections. We used ciprofloxacin to induce a predominantly gram-positive Enterococcus faecalis polymicrobial sepsis in rats. Ciprofloxacin-untreated rats exhibited a predominantly gram-negative polymicrobial sepsis. Rats were subjected to 30% body surface area burn (B), cecal ligation puncture (CLP) with a 22-gauge needle, and B + CLP. Ciprofloxacin-treated B + CLP rats showed a significant decrease in plasma thrombin activatable fibrinolysis inhibitor (TAFI) levels compared with sham rats. However, plasma tissue factor pathway inhibitor (TFPI) levels decreased significantly in B, CLP, and B + CLP groups compared with sham rats. The ciprofloxacin-untreated group showed a significant decrease in plasma TAFI levels in CLP and B + CLP and plasma TFPI levels decreased in all 3 groups compared with sham rats. Histological changes in the liver and kidney included vascular congestion and parenchyma bleed following B + CLP in ciprofloxacin-untreated rats. These results suggest that plasma TAFI and TFPI levels differ depending on the type of bacteria involved in the septic process.<\/jats:p>","DOI":"10.1177\/1076029607305580","type":"journal-article","created":{"date-parts":[[2007,10,2]],"date-time":"2007-10-02T10:48:26Z","timestamp":1191322106000},"page":"362-368","source":"Crossref","is-referenced-by-count":11,"title":["Plasma Thrombin Activatable Fibrinolysis Inhibitor and Tissue Factor Pathway Inhibitor Changes Following Sepsis"],"prefix":"10.1177","volume":"13","author":[{"given":"Thyyar M.","family":"Ravindranath","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Critical Care Medicine, Children's Hospital of New York,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masakatsu","family":"Goto","sequence":"additional","affiliation":[{"name":"Columbia University College of Physicians and Surgeons, New York, New York Burn & Shock Trauma 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