{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T15:47:35Z","timestamp":1777477655325,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:p>The aim of this study was to investigate the hereditary thrombophilic risk factors in patients with venous thromboembolism (VTE) and whether these risk factors play a different role in patients with isolated pulmonary embolism (PE) as compared with patients with deep vein thrombosis (DVT) and patients with PE + DVT. The protein C (PC), protein S, antithrombin activities, homocysteine levels, and factor V Leiden (FVL) G1691A and prothrombin G20210A mutations were evaluated in 191 patients with VTE and 191 controls. The prevalence of FVL and PC deficiency were higher in patients ( P = .003 and P = .02, respectively). There was no significant difference for the other risk factors. The combination of thrombophilic risk factors was significantly higher in patients with DVT + PE as compared with patients with isolated PE or DVT ( P = .04). In conclusion, the most important hereditary risk factors for VTE in this study were the FVL mutation and PC deficiency.<\/jats:p>","DOI":"10.1177\/1076029607305620","type":"journal-article","created":{"date-parts":[[2007,9,25]],"date-time":"2007-09-25T22:43:44Z","timestamp":1190760224000},"page":"168-173","source":"Crossref","is-referenced-by-count":17,"title":["Hereditary Thrombophilic Risk Factors and Venous Thromboembolism in Istanbul, Turkey: The Role in Different Clinical Manifestations of Venous Thromboembolism"],"prefix":"10.1177","volume":"14","author":[{"given":"Gulfer","family":"Okumus","sequence":"first","affiliation":[{"name":"Department of Pulmonary Diseases, Istanbul University, ,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esen","family":"Kiyan","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Diseases, Istanbul 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