{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T15:48:12Z","timestamp":1777477692549,"version":"3.51.4"},"reference-count":14,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2007,12,26]],"date-time":"2007-12-26T00:00:00Z","timestamp":1198627200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2008,10]]},"abstract":"<jats:p>The case of a 16-year-old girl with primary mediastinal large B-cell lymphoma who had thrombosis in the brachiocephalic, subclavian, and internal jugular veins at presentation is reported. MACOP-B chemotherapy plus radiation therapy could be the first-line strategy, but MACOP-B increases the risk of thrombosis. Although an effective method for initial treatment of venous thromboembolism (VTE) in cancer patients has not been established, recent studies revealed that the administration of a low-molecular-weight heparin (LMWH) was effective for secondary prevention of VTE. Therefore, the patient in this case was treated with MACOP-B plus rituximab followed by radiation therapy, and an LMWH was administered through the course of treatment. She achieved complete remission and never suffered from VTE. This case suggests that long-term administration of an LMWH contributes to the primary improvement and secondary prevention of VTE even in patients who are at high risk for thrombosis.<\/jats:p>","DOI":"10.1177\/1076029607313623","type":"journal-article","created":{"date-parts":[[2008,2,5]],"date-time":"2008-02-05T20:24:52Z","timestamp":1202243092000},"page":"468-471","source":"Crossref","is-referenced-by-count":2,"title":["Long-Term Administration of a Low-Molecular-Weight Heparin Contributed to Successful Treatment in a Patient With Primary Mediastinal Large B-Cell Lymphoma and Venous Thromboembolism"],"prefix":"10.1177","volume":"14","author":[{"given":"Akio","family":"Mori","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Hakodate Municipal Hospital, Hakodate, Aiiku Hospital, Sapporo, Japan, , Department of Internal Medicine, Aiiku Hospital, Sapporo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Ibata","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hakodate Municipal Hospital, Hakodate, Aiiku Hospital, Sapporo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinobu","family":"Mashiko","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hakodate Municipal Hospital, Hakodate, Aiiku Hospital, Sapporo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Tsutsumi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hakodate Municipal Hospital, Hakodate, Aiiku Hospital, Sapporo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuo","family":"Masauzi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hakodate Municipal Hospital, Hakodate, Aiiku Hospital, Sapporo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Hashino","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hematology, Aiiku Hospital, Sapporo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanobu","family":"Morioka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hematology, Aiiku Hospital, Sapporo, Japan, Department of Internal Medicine Aiiku Hospital, Sapporo, Japan, Aiiku Hospital, Sapporo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Asaka","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology (M Imamura), Hokkaido University Graduate School of Medicine, Sapporo, Aiiku Hospital, Sapporo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Imamura","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology (M Imamura), Hokkaido University Graduate School of Medicine, Sapporo, Aiiku Hospital, Sapporo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2007,12,26]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(01)00619-2"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19901101)66:9<2027::AID-CNCR2820660930>3.0.CO;2-U"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1995.tb00214.x"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa025313"},{"key":"atypb5","first-page":"1258","volume":"87","author":"Zinzani PL","year":"2002","journal-title":"Haematologica"},{"key":"atypb6","first-page":"50","volume":"76","author":"Dzhumabaeva BT","year":"2004","journal-title":"Ter Arkh"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-102-5-596"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V91.4.1178"},{"key":"atypb9","doi-asserted-by":"crossref","unstructured":"Trousseau A. 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