{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T15:51:24Z","timestamp":1777477884286,"version":"3.51.4"},"reference-count":13,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2008,6,11]],"date-time":"2008-06-11T00:00:00Z","timestamp":1213142400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2010,2]]},"abstract":"<jats:p>This article reports a female who presented with bleeding, acquired factor VIII and von Willebrand factor (aFVIII-VWF) deficiency, and central deficiency in the thyroid and adrenal axis (Sheehan\u2019s syndrome). After starting hormone replacement therapy, relief of bleeding manifestations was associated with correction of both FVIII and VWF to normal. This report draws attention to a rare association between the acquired form of von Willebrand disease and hypothyroidism of central origin.<\/jats:p>","DOI":"10.1177\/1076029608319948","type":"journal-article","created":{"date-parts":[[2008,6,12]],"date-time":"2008-06-12T20:33:43Z","timestamp":1213302823000},"page":"107-109","source":"Crossref","is-referenced-by-count":7,"title":["Acquired Factor VIII and von Willebrand Factor (aFVIII\/VWF) Deficiency and Hypothyroidism in a Case With Hypopituitarism"],"prefix":"10.1177","volume":"16","author":[{"given":"Miriam C.","family":"Oliveira","sequence":"first","affiliation":[{"name":"Discipline of Endocrinology, Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre (UFCSPA), Brasil, , Center of Neuroendocrinology, Santa Casa of Porto Alegre-RS, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline K.","family":"Kramer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Santa Casa of Porto Alegre-RS, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline P.","family":"Marroni","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Santa Casa of Porto Alegre-RS, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina G.S.","family":"Le\u00e3es","sequence":"additional","affiliation":[{"name":"From the Discipline of Endocrinology, Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre (UFCSPA), Brasil, Center of Neuroendocrinology, Santa Casa of Porto Alegre-RS, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciana","family":"Viana","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Santa Casa of Porto Alegre-RS, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e9rgio","family":"Roithman","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Santa Casa of Porto Alegre-RS, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre","family":"Schmaedecke","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Santa Casa of Porto Alegre-RS, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00falia F.S.","family":"Pereira-Lima","sequence":"additional","affiliation":[{"name":"Discipline of Endocrinology, Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre (UFCSPA), Brasil, Center of Neuroendocrinology, Santa Casa of Porto Alegre-RS, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2008,6,11]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03347217"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)92272-0"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1646064"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)90565-4"},{"key":"atypb5","first-page":"1315","volume":"1","author":"MacCallum PK","year":"1987","journal-title":"Lancet"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1016\/0197-0070(91)90459-Y"},{"key":"atypb7","first-page":"284","volume":"2","author":"Levesque H.","year":"1993","journal-title":"Eur J Med"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)82007-4"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.1999.00340.x"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1177\/107602960100700206"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1530\/eje.1.01857"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-0199"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1515\/JPEM.2002.15.3.331"}],"container-title":["Clinical and Applied Thrombosis\/Hemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1076029608319948","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1076029608319948","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:00:10Z","timestamp":1777384810000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1076029608319948"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6,11]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,2]]}},"alternative-id":["10.1177\/1076029608319948"],"URL":"https:\/\/doi.org\/10.1177\/1076029608319948","relation":{},"ISSN":["1076-0296","1938-2723"],"issn-type":[{"value":"1076-0296","type":"print"},{"value":"1938-2723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,6,11]]}}}