{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T03:36:57Z","timestamp":1791862617006,"version":"4.3.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2008,10,7]],"date-time":"2008-10-07T00:00:00Z","timestamp":1223337600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:p>Described is a case of acute chest syndrome in a sickle-cell patient (hemoglobin SS) who also developed signs and symptoms of thrombotic thrombocytopenic purpura, including thrombocytopenia and hemolysis (anemia, elevated lactate dehydrogenase, presence of schistocytes, dark-colored plasma, and elevations in nucleated red blood cells). The ADAMTS13 activity level was normal. Discussed are the diagnosis and therapeutic management issues and the challenges of differentiating the vasoocclusive and hemolytic complications of sickling red blood cells from the thrombotic microangiopathy of thrombotic thrombocytopenic purpura.<\/jats:p>","DOI":"10.1177\/1076029608323804","type":"journal-article","created":{"date-parts":[[2008,10,7]],"date-time":"2008-10-07T20:14:20Z","timestamp":1223410460000},"page":"224-227","source":"Crossref","is-referenced-by-count":22,"title":["Thrombotic Thrombocytopenic Purpura and Sickle Cell Crisis"],"prefix":"10.1177","volume":"16","author":[{"given":"Suresh G.","family":"Shelat","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania,"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2008,10,7]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1097\/PEC.0b013e31815a05e2"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1097\/00062752-200203000-00003"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2005.01436.x"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1002\/jca.20129"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp053024"},{"key":"atypb6","first-page":"868","volume":"3","author":"Baron JM","year":"2005","journal-title":"Clin Adv Hematol Oncol"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V91.8.2839.2839_2839_2846"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1046\/j.0007-1048.2002.03349.x"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.48.7.648"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1985.tb01721.x"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19810815)48:4<954::AID-CNCR2820480417>3.0.CO;2-I"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(94)90136-8"},{"key":"atypb13","first-page":"19","volume":"53","author":"Hiran S.","year":"2005","journal-title":"J Assoc Physicians India"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1081\/HEM-120016371"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200006223422502"},{"key":"atypb16","first-page":"44","volume":"82","author":"Haut MJ","year":"1973","journal-title":"J Lab Clin Med"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.3109\/03630269509005824"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1080\/10245330600938422"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V64.1.282.282"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V72.4.1216.1216"},{"key":"atypb21","first-page":"82","volume":"22","author":"Ayache S.","year":"2007","journal-title":"J Clin Apheresis"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1080\/08880010290097288"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20653"},{"key":"atypb24","author":"Sucker C.","journal-title":"Clin Appl Thromb Hemost"},{"key":"atypb25","volume-title":"Disorders of hemoglobin synthesis","author":"Perkins S.","year":"2006","edition":"4"}],"container-title":["Clinical and Applied Thrombosis\/Hemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1076029608323804","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1076029608323804","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:00:16Z","timestamp":1777384816000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1076029608323804"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10,7]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,4]]}},"alternative-id":["10.1177\/1076029608323804"],"URL":"https:\/\/doi.org\/10.1177\/1076029608323804","relation":{},"ISSN":["1076-0296","1938-2723"],"issn-type":[{"value":"1076-0296","type":"print"},{"value":"1938-2723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,10,7]]}}}