{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T15:51:41Z","timestamp":1777477901179,"version":"3.51.4"},"reference-count":6,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2009,1,13]],"date-time":"2009-01-13T00:00:00Z","timestamp":1231804800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:p>Combined deficiency of the vitamin K-dependent clotting factors (VKCFD) is a rare bleeding disorder involving defective gamma-carboxylation of coagulation factors II , VII, IX and X as well as natural anticoagulants protein C and protein S. The disease is characterized by a cluster of different, often life threatening, bleeding symptoms occurring both spontaneously and in a surgical setting. In the present paper we describe two different treatment modalities to be used both in a programmed surgical procedure and in an emergency scenario. As this disease is a natural model that resembles oral anticoagulation, our experience discloses a possible rationale in the use of recombinant activated FVII for warfarin reversal.<\/jats:p>","DOI":"10.1177\/1076029608330473","type":"journal-article","created":{"date-parts":[[2009,1,14]],"date-time":"2009-01-14T22:29:34Z","timestamp":1231972174000},"page":"221-223","source":"Crossref","is-referenced-by-count":9,"title":["Effective Hemostasis During Minor Surgery in a Case of Hereditary Combined Deficiency of Vitamin K-dependent Clotting Factors"],"prefix":"10.1177","volume":"16","author":[{"given":"Mario","family":"Lapecorella","sequence":"first","affiliation":[{"name":"Haemophilia and Thrombosis Centre, University of L'Aquila, Italy,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariasanta","family":"Napolitano","sequence":"additional","affiliation":[{"name":"Haemophilia and Thrombosis Centre, University of L'Aquila, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Bernardi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, University of Ferrara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirko","family":"Pinotti","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, University of Ferrara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piero Sandro","family":"Sbrighi","sequence":"additional","affiliation":[{"name":"Transfusion Service, Colleferro Hospital, Colleferro, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"Marchetti","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, University of Ferrara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Canella","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, University of Ferrara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierpaolo","family":"Caruso","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, University of Ferrara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Assunta","family":"Orecchioni","sequence":"additional","affiliation":[{"name":"Haemophilia and Thrombosis Centre, University of L'Aquila, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guglielmo","family":"Mariani","sequence":"additional","affiliation":[{"name":"Haemophilia and Thrombosis Centre, University of L'Aquila, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2009,1,13]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2005.01478.x"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2004.00857.x"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1038\/nature02214"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1097\/01.mbc.0000183634.68071.3b"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1161\/ATVB.16v01.0072"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2003.008904"}],"container-title":["Clinical and Applied Thrombosis\/Hemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1076029608330473","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1076029608330473","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:00:20Z","timestamp":1777384820000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1076029608330473"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1,13]]},"references-count":6,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,4]]}},"alternative-id":["10.1177\/1076029608330473"],"URL":"https:\/\/doi.org\/10.1177\/1076029608330473","relation":{},"ISSN":["1076-0296","1938-2723"],"issn-type":[{"value":"1076-0296","type":"print"},{"value":"1938-2723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,1,13]]}}}