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Platelet expression of CD40L and CD62P and expression of CD40 on monocytes and platelet\u2014monocyte aggregates were determined by flow cytometry in whole blood from 23 preeclamptic women, 23 normotensive pregnant women, and 23 nonpregnant women. The preeclamptic women showed a significant increase in CD40L and CD62P on platelets and in CD40 on monocytes when compared with normotensive pregnant women and nonpregnant women (all P &lt; .001). There was a significant increase in platelet\u2014monocyte aggregates in preeclamptic women (P &lt; .001) and normotensive pregnant women (P = .003) compared with nonpregnant women. Preeclampsia is associated with activation of the CD40\u2014CD40L system. The activation of this system may contribute to the development or maintenance of the proinflammatory and prothrombotic milieu found in preeclampsia.<\/jats:p>","DOI":"10.1177\/1076029608331229","type":"journal-article","created":{"date-parts":[[2009,2,16]],"date-time":"2009-02-16T20:33:48Z","timestamp":1234816428000},"page":"306-312","source":"Crossref","is-referenced-by-count":12,"title":["Flow Cytometric Investigation of CD40-CD40 Ligand System in Preeclampsia and Normal Pregnancy"],"prefix":"10.1177","volume":"16","author":[{"given":"Tzvetan Hristoforov","family":"Lukanov","sequence":"first","affiliation":[{"name":"Immunology Laboratory, University Hospital, Pleven,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Svetla Ivanova","family":"Bojinova","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University Hospital, Pleven"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanya 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