{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T05:29:14Z","timestamp":1785821354414,"version":"3.56.0"},"reference-count":29,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2009,6,10]],"date-time":"2009-06-10T00:00:00Z","timestamp":1244592000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:p>\n                    Introduction: Genetic polymorphisms that are found among factors of the coagulation cascade are factor V leiden mutation (FVL), prothrombin (PT), and methylenetetrahydrofolate reductase (MTHFR), reported for thrombotic complications. We have investigated the associations of these gene polymorphisms in patients with end-stage renal disease (ESRD). Methods: We genotyped 258 patients for FV G1691A, PT G20210A, and MTHFR (C677T, A1298C) gene by using polymerase chain reaction\u2014restriction fragment length polymorphism (PCR-RFLP) analysis and were compared with 569 healthy controls. Serum folate, total homocysteine (tHcys), and vitamin B\n                    <jats:sub>12<\/jats:sub>\n                    were measured in both patients with ESRD and controls. Results: No homozygous individuals for the mutant AA genotype of FVL G1691A were observed in this study. The frequency of the heterozygous genotypes was (11.2%), which was nearly 3 times higher than that observed in controls (3.2%), with a odds ratio of 3.87 (P = .0001, 95% CI = 2.11-7.11). PT G20210A mutation was missing in both patients and the controls. At MTHFR locus, TT genotype of C677T was present in 9.6% among ESRD, while CC genotype of A1298C was present in 11.7% of the ESRD. In control group, it was significantly low that is, 4.2% and 3.2%, respectively (P = .0034; OR = 2.44, 95% CI = 1.36-4.36 and P &lt; .0001; OR = 4.03; 95% CI = 2.2-7.37). The combined analysis of the 2 genotypes showed further increased risk in ESRD ~15 folds. Further, the carrier of TT and CC genotypes of C677T and A1298C had significantly higher total homocysteine (tHcys) level than those with CC and AA genotypes (P &lt; .001). Conclusion: The carrier of FVL, TT genotype of C677T, and CC genotype of A1298C polymorphisms may act as risk factors for ESRD.\n                  <\/jats:p>","DOI":"10.1177\/1076029609335911","type":"journal-article","created":{"date-parts":[[2009,6,11]],"date-time":"2009-06-11T20:14:28Z","timestamp":1244751268000},"page":"132-140","source":"Crossref","is-referenced-by-count":8,"title":["Role of Thrombotic Risk Factors in End-Stage Renal Disease"],"prefix":"10.1177","volume":"16","author":[{"given":"Gaurav","family":"Tripathi","sequence":"first","affiliation":[{"name":"Department of Urology, CSSMU, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Satya Narayan Sankhwar","sequence":"additional","affiliation":[{"name":"Department of Urology, CSSMU, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Raj Kumar Sharma","sequence":"additional","affiliation":[{"name":"Department of Nephrology, SGPGIMS, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Vinod Pandirikkal Baburaj","sequence":"additional","affiliation":[{"name":"Department of Nephrology, SGPGIMS, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suraksha","family":"Agrawal","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, SGPGIMS, Lucknow, Uttar Pradesh, India,"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2009,6,10]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfl400"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181817d36"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-139X.2007.00243.x"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1007\/s003359900838"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a010290"},{"key":"atypb6","unstructured":"Ralph C., Jacobsen DW Homocysteine in Health and Disease. Cambridge, UK: Cambridge University Press; 2001:92-112."},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2006.05.018"},{"issue":"10","key":"atypb8","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1681\/ASN.V11101918","volume":"11","author":"Manuela F.","year":"2000","journal-title":"J Am Soc Nephrol"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.2165\/00066982-200005010-00013"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.22.3.484"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1656059"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2007.48.2.201"},{"issue":"4","key":"atypb13","first-page":"230","volume":"40","author":"Hultberg B.","year":"1993","journal-title":"Clin Nephrol"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1038\/ng0595-111"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38611.658947.55"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-006-0290-2"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1177\/089686080502503S21"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000013299.11876.F6"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1086\/301825"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1006\/mgme.1998.2714"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djj262"},{"issue":"8","key":"atypb22","first-page":"720","volume":"72","author":"DarrinCox E.","year":"2001","journal-title":"Transplantation"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.200700114"},{"key":"atypb24","doi-asserted-by":"publisher","DOI":"10.1038\/369064a0"},{"key":"atypb25","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2005.00483.x"},{"key":"atypb26","first-page":"162","volume":"1","author":"Breslow NE","year":"1980","journal-title":"Int Agency Res. Cancer"},{"key":"atypb27","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-1345(00)02440-4"},{"key":"atypb28","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-007-9610-7"},{"key":"atypb29","doi-asserted-by":"publisher","DOI":"10.1038\/7594"}],"container-title":["Clinical and Applied Thrombosis\/Hemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1076029609335911","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1076029609335911","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:00:22Z","timestamp":1777384822000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1076029609335911"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6,10]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,4]]}},"alternative-id":["10.1177\/1076029609335911"],"URL":"https:\/\/doi.org\/10.1177\/1076029609335911","relation":{},"ISSN":["1076-0296","1938-2723"],"issn-type":[{"value":"1076-0296","type":"print"},{"value":"1938-2723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,6,10]]}}}