{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T15:52:04Z","timestamp":1777477924406,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2009,7,31]],"date-time":"2009-07-31T00:00:00Z","timestamp":1248998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2010,6]]},"abstract":"<jats:p>Background: Most patients with malignant diseases are frequently complicated with some type of thrombosis, such as disseminated intravascular coagulation (DIC) or deep vein thrombosis (DVT)\/pulmonary embolism (PE). Objective: The cohort and retrospective study was designed to examine the frequency of thrombosis in patients with malignant diseases and to evaluate the efficacy of D-dimer and soluble fibrin (SF) for the diagnosis of thrombosis. Patients\/Methods: The plasma concentrations of D-dimer and SF were measured in patients with malignant diseases suspected of having thrombosis. D-dimer and SF were measured using a latex aggregation assay. Results: Thrombosis was observed in 23.3% of the patients with malignant diseases. Disseminated intravascular coagulation was frequently observed in patients with hepatoma, and DVT\/PE was frequently observed in patients with colon cancer, lung cancer, and uterine cancer. The plasma levels of D-dimer and SF were increased in malignant diseases, especially hepatoma. Plasma levels of D-dimer and SF were significantly higher in patients with thrombosis in comparison to patients without thrombosis. A receiver operating characteristic (ROC) analysis showed the D-dimer and SF levels to be useful in the diagnosis of thrombosis. Conclusion: Elevated D-dimer and SF levels might indicate a high risk of thrombosis in patients with malignant disease; however, these assays still need to be standardized.<\/jats:p>","DOI":"10.1177\/1076029609340901","type":"journal-article","created":{"date-parts":[[2009,7,31]],"date-time":"2009-07-31T20:25:43Z","timestamp":1249071943000},"page":"266-272","source":"Crossref","is-referenced-by-count":5,"title":["Elevated Fibrin-Related Markers in Patients with Malignant Diseases Suspected of Having Thrombotic Disorders"],"prefix":"10.1177","volume":"16","author":[{"given":"Hideki","family":"Nomura","sequence":"first","affiliation":[{"name":"Department of Oncology, Mie University Graduate School of Medicine, Tsu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideo","family":"Wada","sequence":"additional","affiliation":[{"name":"Department of Molecular and Laboratory Medicine,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiro","family":"Mizuno","sequence":"additional","affiliation":[{"name":"Department of Oncology, Mie University Graduate School of Medicine, Tsu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiki","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Department of Oncology, Mie University Graduate School of Medicine, Tsu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanako","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Oncology, Mie University Graduate School of Medicine, Tsu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigehisa","family":"Kitano","sequence":"additional","affiliation":[{"name":"Department of Oncology, Mie University Graduate School of Medicine, Tsu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoyuki","family":"Katayama","sequence":"additional","affiliation":[{"name":"Department of Hematology, Mie University Graduate School of Medicine, Tsu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norikazu","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Mie University Graduate School of Medicine, Tsu, Japan, Department of Obstetrics and Gynecology, , Mie University Graduate School of Medicine, Tsu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Sugiyama","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, , Mie University Graduate School of Medicine, Tsu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Sudo","sequence":"additional","affiliation":[{"name":"The First Department of Surgery Mie University Graduate School of Medicine, Tsu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanobu","family":"Usui","sequence":"additional","affiliation":[{"name":"The First Department of Surgery Mie University Graduate School of Medicine, Tsu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuji","family":"Isaji","sequence":"additional","affiliation":[{"name":"The First Department of Surgery, Mie University Graduate School of Medicine, Tsu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsutomu","family":"Nobori","sequence":"additional","affiliation":[{"name":"Department of Molecular and Laboratory Medicine, , Mie University Graduate School of Medicine, Tsu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2009,7,31]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1080\/07357900802563028"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-10-053736"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1177\/107602960200800103"},{"issue":"1","key":"atypb4","first-page":"13","volume":"344","author":"Wada H.","year":"2004","journal-title":"CCA"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2003.10.003"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1002\/hon.687"},{"issue":"3","key":"atypb7","first-page":"179","volume":"27","author":"Wada H.","year":"2005","journal-title":"Exp Oncol"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1079262"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2008.253"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2008.656"},{"issue":"6","key":"atypb11","first-page":"1176","volume":"100","author":"Akl EA","year":"2008","journal-title":"A systematic review. 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