{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T17:23:22Z","timestamp":1778261002589,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2009,10,13]],"date-time":"2009-10-13T00:00:00Z","timestamp":1255392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:p>Heparin-induced thrombocytopenia (HIT) is a life-threatening immune response to heparin that is associated with a high risk of thromboembolic complications. The syndrome is caused by antibodies that are reactive against complexes of platelet factor 4\/heparin (PF4\/H). For patients with HIT, the discontinuation of heparin alone is not sufficient and the diagnosis necessitates the administration of an alternative anticoagulant. Fondaparinux is a synthetic pentasaccharide that binds to antithrombin and potentiates inhibition of factor Xa. Data have shown that fondaparinux is structurally too short to induce an antibody response and could be a useful agent to treat HIT. In our hospital, we retrospectively analyzed the use of fondaparinux in the treatment of 24 patients with acute HIT during unfractionated heparin (UFH) or low-molecular-weight heparin (LMWH) administration and compared the results to a similar population of 20 patients who were treated with lepirudin. The treated patients had a complete platelet count recovery, and none experienced a new thromboembolic complication or major bleeding. The development of limb gangrene (2 patients who received lepirudin and 1 who received fondaparinux) likely resulted from a delay in diagnosis and treatment initiation. Our data suggest that fondaparinux may be considered a safe and an effective alternative treatment in HIT complicated with or without thrombosis.<\/jats:p>","DOI":"10.1177\/1076029609347900","type":"journal-article","created":{"date-parts":[[2009,10,13]],"date-time":"2009-10-13T23:59:37Z","timestamp":1255478377000},"page":"663-667","source":"Crossref","is-referenced-by-count":55,"title":["Fondaparinux for the Treatment of Acute Heparin-Induced Thrombocytopenia: A Single-Center Experience"],"prefix":"10.1177","volume":"16","author":[{"given":"Elisavet","family":"Grouzi","sequence":"first","affiliation":[{"name":"Transfusion Medicine Department, KAT General Hospital, Athens, Greece,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elias","family":"Kyriakou","sequence":"additional","affiliation":[{"name":"Transfusion Medicine Department, KAT General Hospital, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioannis","family":"Panagou","sequence":"additional","affiliation":[{"name":"Transfusion Medicine Department, KAT General Hospital, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioanna","family":"Spiliotopoulou","sequence":"additional","affiliation":[{"name":"Transfusion Medicine Department, KAT General Hospital, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2009,10,13]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1538-7836.2003.00270.x"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-0677"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04334.x"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2006.06018.x"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1309\/D79K4YG78NTNYY38"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-005-1849-9"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200103013440901"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011100"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-05-1938"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-05-2010"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1378\/chest.127.2_suppl.1S"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1080\/10245330500093492"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2004.01039.x"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2008.03025.x"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.07401.x"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1046\/j.1538-7836.2003.0468c.x"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V104.11.1775.1775"},{"issue":"8","key":"atypb18","first-page":"1017","volume":"89","author":"Harenberg J.","year":"2004","journal-title":"Haematologica"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1616573"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S2633"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1160\/TH07-04-0252"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1186\/1477-9560-6-9"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc070346"},{"key":"atypb24","doi-asserted-by":"publisher","DOI":"10.1160\/TH07-09-0573"},{"key":"atypb25","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2008.02972.x"}],"container-title":["Clinical and Applied Thrombosis\/Hemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1076029609347900","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1076029609347900","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:00:52Z","timestamp":1777384852000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1076029609347900"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10,13]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["10.1177\/1076029609347900"],"URL":"https:\/\/doi.org\/10.1177\/1076029609347900","relation":{},"ISSN":["1076-0296","1938-2723"],"issn-type":[{"value":"1076-0296","type":"print"},{"value":"1938-2723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,10,13]]}}}