{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T15:53:41Z","timestamp":1777478021201,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2010,3,8]],"date-time":"2010-03-08T00:00:00Z","timestamp":1268006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:p>\n                    Thrombotic thrombocytopenic purpura (TTP) is characterized by disseminated thrombotic occlusions located in the microcirculation and a syndrome of microangiopathic hemolytic anemia, thrombocytopenia, fever, and renal and neurologic abnormalities. Thrombotic thrombocytopenic purpura is encountered in a variety of clinical situations such as viral, bacterial, and mycobacterial infections, autoimmune disorders, drug reactions, connective tissue disease, and solid tumors. In this report, we present TTP in a case of brucellosis because of rare presentation. A 7-year-old girl was admitted with the complaints of headache, fever, hematuria, malaise, jaundice, epistaxis, and purpura. Her physical examination revealed conjunctival pallor, scleral icterus, petechial-purpuric skin lesions on both legs, and confusion. Laboratory tests showed hematocrit 14%; hemoglobin 4.8 g\/dL; platelet count 6000\/mm\n                    <jats:sup>3<\/jats:sup>\n                    , and reticulocytosis 6%. Peripheral blood smear revealed fragmented red blood cells and a complete absence of platelets. The clinical and laboratory findings were consistent with TTP. Serum antibrucella titration agglutination test was found to be 1\/1280 positive.\n                  <\/jats:p>","DOI":"10.1177\/1076029609356426","type":"journal-article","created":{"date-parts":[[2010,3,8]],"date-time":"2010-03-08T23:23:56Z","timestamp":1268090636000},"page":"245-247","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Thrombotic Thrombocytopenic Purpura in a Case of Brucellosis"],"prefix":"10.1177","volume":"17","author":[{"given":"Sinan","family":"Akbayram","sequence":"first","affiliation":[{"name":"Department of Pediatric Hematology, Yuzuncu Yil University, Van, Turkey,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murat","family":"Dogan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Yuzuncu Yil University, Van, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erdal","family":"Peker","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Yuzuncu Yil University, Van, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cihangir","family":"Akgun","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Yuzuncu Yil University, Van, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet Faik","family":"Oner","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology, Yuzuncu Yil University, Van, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00fcseyin","family":"Caksen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Yuzuncu Yil University, Van, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2010,3,8]]},"reference":[{"key":"atypb1","volume-title":"Manual of Pediatric Hematology and Oncology","author":"Lanzkowsky P.","year":"2005","edition":"4"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0b013e3180d09f19"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1159\/000102159"},{"key":"atypb4","volume-title":"General Directorate of Primary Health Services","author":"Ministry of Health of Turkey.","year":"2005"},{"issue":"1","key":"atypb5","first-page":"21","volume":"11","author":"Haji-Abdolbagi M.","year":"2008","journal-title":"Arch Iran Med"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/50.3.153"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1016\/S1201-9712(02)90108-6"},{"issue":"5","key":"atypb8","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.26719\/2003.9.5-6.1054","volume":"9","author":"Salari MH","year":"2003","journal-title":"East Mediterr Health J"},{"issue":"6","key":"atypb9","doi-asserted-by":"crossref","first-page":"362","DOI":"10.7883\/yoken.JJID.2007.362","volume":"60","author":"Minas M.","year":"2007","journal-title":"Jpn J Infect Dis"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1557054"},{"key":"atypb11","volume-title":"Brucellosis","author":"Al-Nassir W.","year":"2009"},{"issue":"1","key":"atypb12","first-page":"63","volume":"52","author":"Akdeniz H.","year":"1998","journal-title":"Acta Med Okayama"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1986.tb01746.x"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1159\/000204504"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1080\/003655402320208785"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20386"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199607000-00003"},{"key":"atypb18","unstructured":"Scott PJ, Montgomery RR Hemorrhagic and thrombotic diseases. In: Kliegman MR, Behrman RE, Jenson HB, Stanton BF , eds. Nelson Textbook of Pediatrics. 18th ed. Philadelphia: Saunders Elsevier ; 2007:2060-2089."},{"key":"atypb19","unstructured":"McCrae KR , Sadler JE, Cines D. Thrombotic thrombocytopenic purpura and the hemolytic uremic syndrome. In: Hoffman R, Benz EJ Jr, Shattil SJ , eds. Hematology: Basic Principles and Practice. 4th ed. 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