{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T16:16:49Z","timestamp":1787156209043,"version":"build-2736575974"},"reference-count":47,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2010,5,11]],"date-time":"2010-05-11T00:00:00Z","timestamp":1273536000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:p>Fibrin monomers inhibit surfactant function. 4G\/5G insertion\/deletion polymorphism plays an important role in the regulation of plasminogen activator inhibitor 1 (PAI-1) gene expression. To examine the genotype distribution of PAI-1 polymorphism in 60 infants with respiratory distress syndrome (RDS) and 53 controls, an allele-specific polymerase chain reaction (PCR) was used. The proportion of 4G\/4G, 4G\/5G, and 5G\/5G genotypes did not differ statistically between the RDS and control groups (P &gt; .05). Having PAI-1 4G\/4G genotype polymorphism appears to increase the risk of RDS (odds ratio [OR] =1.5; 95% confidence interval [CI], 0.5-4.3), although it was not statistically significant. No relation was found between the PAI-1 4G\/5G polymorphisms and RDS, but there was an increased risk associated with the 4G variant of the PAI-1 gene. We believe that our findings of increased 4G allele of the PAI-1 gene in infants with RDS would also help to clarify the pathogenesis of RDS.<\/jats:p>","DOI":"10.1177\/1076029610369796","type":"journal-article","created":{"date-parts":[[2010,5,11]],"date-time":"2010-05-11T20:40:22Z","timestamp":1273610422000},"page":"352-357","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Plasminogen Activator Inhibitor I 4G\/5G Polymorphism in Neonatal Respiratory Distress Syndrome"],"prefix":"10.1177","volume":"17","author":[{"given":"Didem","family":"Armangil","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Neonatology Unit, Faculty of Medicine, Hacettepe University, Ankara, Turkey,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Yurdak\u00f6k","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Neonatology Unit, Faculty of Medicine, Hacettepe University, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamza","family":"Okur","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Hematology Unit, Faculty of Medicine, Hacettepe University, Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aytemiz","family":"G\u00fcrgey","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Hematology Unit, Faculty of Medicine, Hacettepe University, Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2010,5,11]]},"reference":[{"issue":"1","key":"atypb1","first-page":"64","volume":"17","author":"Gitlin D.","year":"1956","journal-title":"Pediatrics"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb\/9.2.213"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.3.1053"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200205001-00017"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199602000-00007"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000057870.61079.3E"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1038\/35025229"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2008.07.018"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.98.11040912"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-0870"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.18.6776"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1042\/bj3141041"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1986.tb04532.x"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.6.1851"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/45.8.1141"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2007.02724.x"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(68)91871-0"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1378\/chest.105.1.268"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb\/9.3.239"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199411000-00020"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199701000-00019"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.10060"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830420222"},{"key":"atypb24","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8652(199603)51:3<247::AID-AJH16>3.0.CO;2-D"},{"issue":"4","key":"atypb25","first-page":"489","volume":"41","author":"Yurdak\u00f6k M.","year":"1999","journal-title":"Turk J Pediatr"},{"key":"atypb26","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2001.03175.x"},{"key":"atypb27","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-3278(97)90431-2"},{"key":"atypb28","doi-asserted-by":"publisher","DOI":"10.2337\/diab.44.1.37"},{"key":"atypb29","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.117260"},{"key":"atypb30","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118396"},{"key":"atypb31","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199904010-00020"},{"issue":"9178","key":"atypb32","first-page":"556","volume":"354","author":"Hermans PW","year":"1999","journal-title":"Meningococcal Research Group. 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