{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T22:17:14Z","timestamp":1790201834402,"version":"4.1.0"},"reference-count":17,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2010,6,13]],"date-time":"2010-06-13T00:00:00Z","timestamp":1276387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:p>Objective: To determine whether dosage adjustment of enoxaparin during pregnancy, to maintain a peak anti-Xa of 1.0 to 1.2 U\/mL, is safe for women with mechanical prosthetic heart valves (MPHV). Design: A prospective observational study. Setting: This study was performed at Charlotte Maxeke Johannesburg Academic Hospital from 2007 to 2009. Population: Fifteen women with MPHVs. Methods: Women were treated with enoxaparin with dosage adjustment to achieve a peak anti-Xa of 1.0 to 1.2 U\/ mL. Main Outcome Measures: Main outcomes measured were prosthetic valve thrombosis, bleeding, and maternal mortality. Results: There was no maternal mortality. None of the women developed valvular thrombosis during pregnancy. In all, 2 women developed epistaxis and another developed spotting per vaginum. Conclusion: Our data show that enoxaparin may be administered safely during pregnancy to pregnant women with MPHV when there is dosage adjustment throughout pregnancy to maintain an anti-Xa of 1.0 to 1.2 U\/mL.<\/jats:p>","DOI":"10.1177\/1076029610371470","type":"journal-article","created":{"date-parts":[[2010,6,14]],"date-time":"2010-06-14T22:09:19Z","timestamp":1276553359000},"page":"313-319","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":26,"title":["A Prospective Trial Showing the Safety of Adjusted-Dose Enoxaparin for Thromboprophylaxis of Pregnant Women With Mechanical Prosthetic Heart Valves"],"prefix":"10.1177","volume":"17","author":[{"family":"Chitsike Rufaro Saeed","sequence":"first","affiliation":[{"name":"Department of Haematology, University of the Witwatersrand, Charlotte Maxeke Johannesburg Academic Hospital and National Health Laboratory Service (NHLS), Johannesburg, South 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