{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T12:06:46Z","timestamp":1780056406537,"version":"3.54.0"},"reference-count":20,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2010,8,10]],"date-time":"2010-08-10T00:00:00Z","timestamp":1281398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2011,2]]},"abstract":"<jats:p>Background: Acquired platelet function defects (PFDs) remain poorly characterized, underrecognized, and therefore understudied. Patients\/Methods: Clinical and laboratory records of 109 patients with acquired PFDs diagnosed over 5 years were analyzed. Screening studies (platelet count, prothrombin time, activated partial thromboplastin time, and thrombin time), template bleeding time, platelet factor 3 (PF-3) availability test, light-transmission aggregometry, and further testing as indicated were performed. Results: 64 patients had mild and 26 had major bleeding. In all, 15 were referred for preoperative testing, whereas 4 had thrombotic events. Causes and associations of PFDs were drug-induced (34), idiopathic (34), hematopoietic neoplasms (15; myeloma 4, Waldenstrom macroglobulinemia 2, chronic myeloid leukemia 4, essential thrombocythaemia 3, and primary myelofibrosis and chronic lymphocytic leukemia 1 each), chronic liver disease (4), postcardiac surgery (2), uremia (2), and thalassemia major (7). Miscellaneous disorders comprised the rest. Conclusions: Acquired PFDs span a wide range of disease settings. Systematic, sequential laboratory testing identifies patterns of dysfunction, excludes inherited disorders, and streamlines management.<\/jats:p>","DOI":"10.1177\/1076029610379397","type":"journal-article","created":{"date-parts":[[2010,8,10]],"date-time":"2010-08-10T20:53:46Z","timestamp":1281473626000},"page":"88-93","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Acquired Platelet Dysfunction in 109 Patients From a Tertiary Care Referral Hospital"],"prefix":"10.1177","volume":"17","author":[{"given":"Prashant","family":"Sharma","sequence":"first","affiliation":[{"name":"Haematology Department, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakhee","family":"Kar","sequence":"additional","affiliation":[{"name":"Haematology Department, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Bhargava","sequence":"additional","affiliation":[{"name":"Haematology Department, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi","family":"Ranjan","sequence":"additional","affiliation":[{"name":"Haematology Department, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Pravas Chandra Mishra","sequence":"additional","affiliation":[{"name":"Haematology Department, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renu","family":"Saxena","sequence":"additional","affiliation":[{"name":"Haematology Department, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India,"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2010,8,10]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1177\/1076029609334123"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2007.06.001"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19810101)47:1<207::AID-CNCR2820470134>3.0.CO;2-6"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-004-0872-9"},{"key":"atypb5","doi-asserted-by":"crossref","unstructured":"Saxena R., Pati HP, Kannan M., Ahmad F. 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