{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T15:55:47Z","timestamp":1777478147011,"version":"3.51.4"},"reference-count":52,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2011,10,17]],"date-time":"2011-10-17T00:00:00Z","timestamp":1318809600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:p>We studied the ability of a new instrument, the PlaCor PRT that measures shear-induced platelet aggregation in fingerstick, non-anticoagulated blood without added agonists, to detect platelet dysfunction ex vivo. Platelet reactivity time (PRT) and whole blood aggregation (WBA) were measured in 160 healthy volunteers, before and after aspirin and in 170 participants with established vascular disease or risk factors thereof treated with aspirin \u00b1 clopidogrel. Pretreatment PRT and WBA were significantly correlated (collagen r = \u2212.63; arachidonate r = \u2212.65; P &lt; .0001). Following aspirin, the mean PRT increased from 82 to 142 seconds ( P &lt; .0001), and in participants treated with clopidogrel\u2013aspirin, the mean PRT (286 seconds, n = 65) was significantly longer than with aspirin alone (166 seconds, n = 105; P &lt; .001). Only 13% of PRTs of participants treated with clopidogrel and aspirin were within the normal range. We conclude that the PlaCor PRT is a simple, rapid, point-of-care instrument that compares favorably with published descriptions of other platelet function instruments.<\/jats:p>","DOI":"10.1177\/1076029611423387","type":"journal-article","created":{"date-parts":[[2011,10,18]],"date-time":"2011-10-18T20:15:54Z","timestamp":1318968954000},"page":"140-149","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Measurement of Shear-Activated Platelet Aggregate Formation in Non-Anticoagulated Blood: Utility in Detection of Clopidogrel\u2013Aspirin-Induced Platelet Dysfunction"],"prefix":"10.1177","volume":"18","author":[{"given":"Gerhard J.","family":"Johnson","sequence":"first","affiliation":[{"name":"Hematology-Oncology Section, Medical Service, Veterans Affairs Health Care System, Minneapolis, MN, USA"},{"name":"Hematology, Oncology and Transplant Division, Department of Medicine, University of Minnesota, Minneapolis, MN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anish V.","family":"Sharda","sequence":"additional","affiliation":[{"name":"Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gundu H. R.","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark H.","family":"Ereth","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Anesthesia, Mayo Clinic, Rochester, MN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David D.","family":"Laxson","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Department of Medicine, University of Minnesota, Minneapolis, MN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Whyte G.","family":"Owen","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology and Department of Hematology Research, Mayo Clinic, Rochester, MN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,10,17]]},"reference":[{"key":"bibr1-1076029611423387","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.675991"},{"key":"bibr2-1076029611423387","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2008.08.048"},{"key":"bibr3-1076029611423387","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.900589"},{"key":"bibr4-1076029611423387","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2009.03699.x"},{"key":"bibr5-1076029611423387","doi-asserted-by":"publisher","DOI":"10.1160\/TH09-05-0284"},{"key":"bibr6-1076029611423387","doi-asserted-by":"publisher","DOI":"10.1160\/TH09-06-0418"},{"key":"bibr7-1076029611423387","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.181"},{"key":"bibr8-1076029611423387","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2006.11.012"},{"key":"bibr9-1076029611423387","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2008.11.019"},{"key":"bibr10-1076029611423387","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.696732"},{"key":"bibr11-1076029611423387","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2010.04.017"},{"key":"bibr12-1076029611423387","doi-asserted-by":"publisher","DOI":"10.1160\/TH09-05-0285"},{"key":"bibr13-1076029611423387","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0b013e328332dbd4"},{"key":"bibr14-1076029611423387","doi-asserted-by":"publisher","DOI":"10.1160\/TH09-12-0832"},{"key":"bibr15-1076029611423387","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2009.11.005"},{"key":"bibr16-1076029611423387","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.09.067"},{"key":"bibr17-1076029611423387","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2008.11.020"},{"key":"bibr18-1076029611423387","doi-asserted-by":"publisher","DOI":"10.1160\/TH09-06-0367"},{"key":"bibr19-1076029611423387","doi-asserted-by":"publisher","DOI":"10.1160\/TH07-08-0530"},{"key":"bibr20-1076029611423387","doi-asserted-by":"publisher","DOI":"10.2217\/fca.10.20"},{"key":"bibr21-1076029611423387","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V88.5.1525.1525"},{"key":"bibr22-1076029611423387","doi-asserted-by":"publisher","DOI":"10.1080\/09537100400010352"},{"key":"bibr23-1076029611423387","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1955"},{"key":"bibr24-1076029611423387","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-04-278812"},{"key":"bibr25-1076029611423387","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2010.05.030"},{"key":"bibr26-1076029611423387","doi-asserted-by":"publisher","DOI":"10.1039\/B916757A"},{"key":"bibr27-1076029611423387","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1220324"},{"key":"bibr28-1076029611423387","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn419"},{"key":"bibr29-1076029611423387","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0b013e31818524c1"},{"key":"bibr30-1076029611423387","doi-asserted-by":"publisher","DOI":"10.1160\/TH08-09-0577"},{"issue":"2","key":"bibr31-1076029611423387","first-page":"404","volume":"102","author":"Blais N","year":"2009","journal-title":"Thromb Haemost"},{"key":"bibr32-1076029611423387","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(01)01631-9"},{"key":"bibr33-1076029611423387","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2003.12.034"},{"key":"bibr34-1076029611423387","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2009.04.027"},{"key":"bibr35-1076029611423387","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-5922.2010.00170.x"},{"key":"bibr36-1076029611423387","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2007.12.034"},{"key":"bibr37-1076029611423387","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2008.09.004"},{"key":"bibr38-1076029611423387","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.06.049"},{"key":"bibr39-1076029611423387","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M410235200"},{"key":"bibr40-1076029611423387","doi-asserted-by":"publisher","DOI":"10.3233\/BIR-1995-32106"},{"key":"bibr41-1076029611423387","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V71.5.1366.1366"},{"key":"bibr42-1076029611423387","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-009-0397-0"},{"key":"bibr43-1076029611423387","doi-asserted-by":"publisher","DOI":"10.1080\/10739680802651477"},{"key":"bibr44-1076029611423387","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2008.03188.x"},{"key":"bibr45-1076029611423387","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-009-0881-9"},{"key":"bibr46-1076029611423387","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2009.12.020"},{"key":"bibr47-1076029611423387","doi-asserted-by":"publisher","DOI":"10.1080\/09537100400028800"},{"key":"bibr48-1076029611423387","doi-asserted-by":"publisher","DOI":"10.1080\/09537100902745117"},{"key":"bibr49-1076029611423387","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2007.10.018"},{"key":"bibr50-1076029611423387","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2010.03.008"},{"key":"bibr51-1076029611423387","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2009.04.016"},{"key":"bibr52-1076029611423387","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq023"}],"container-title":["Clinical and Applied Thrombosis\/Hemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1076029611423387","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1076029611423387","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1076029611423387","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:01:37Z","timestamp":1777384897000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1076029611423387"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10,17]]},"references-count":52,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["10.1177\/1076029611423387"],"URL":"https:\/\/doi.org\/10.1177\/1076029611423387","relation":{},"ISSN":["1076-0296","1938-2723"],"issn-type":[{"value":"1076-0296","type":"print"},{"value":"1938-2723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,10,17]]}}}