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Thirty-one (42.5%) of them were asymptomatic. Out of symptomatic patients, 17 had severe clinical symptoms, whereas 8 presented with moderate and 17 with mild symptoms. The symptoms listed in order of frequency were as follows: epistaxis, petechia or ecchymose, easy bruising, and oral cavity bleeding. The genotype was determined in 8 patients. Recombinant activated factor VII (rFVIIa) was used to treat 49 bleeding episodes in 8 patients after 2002. In 2 patients with repeated central nervous system bleeding prophylaxis with rFVIIa was administered. No allergic and thrombotic events were observed during both treatment and prophylaxis courses. Antibody occurrence was not detected in the patients during treatment.<\/jats:p>","DOI":"10.1177\/1076029611435091","type":"journal-article","created":{"date-parts":[[2012,2,12]],"date-time":"2012-02-12T20:24:11Z","timestamp":1329078251000},"page":"588-593","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Factor VII Deficiency"],"prefix":"10.1177","volume":"18","author":[{"given":"Zafer","family":"Salcioglu","sequence":"first","affiliation":[{"name":"Pediatric Haematology\u2013Oncology Clinic, Bakirkoy Children\u2019s and Maternity Education and Research Hospital, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arzu","family":"Akcay","sequence":"additional","affiliation":[{"name":"Pediatric Haematology\u2013Oncology Clinic, Bakirkoy Children\u2019s and Maternity Education and Research Hospital, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hulya Sayilan","family":"Sen","sequence":"additional","affiliation":[{"name":"Pediatric Haematology\u2013Oncology Clinic, Bakirkoy Children\u2019s and Maternity Education and Research Hospital, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gonul","family":"Aydogan","sequence":"additional","affiliation":[{"name":"Pediatric Haematology\u2013Oncology Clinic, Bakirkoy Children\u2019s and Maternity Education and Research Hospital, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferhan","family":"Akici","sequence":"additional","affiliation":[{"name":"Pediatric Haematology\u2013Oncology Clinic, Bakirkoy Children\u2019s and Maternity Education and Research Hospital, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deniz","family":"Tugcu","sequence":"additional","affiliation":[{"name":"Pediatric Haematology\u2013Oncology Clinic, Bakirkoy Children\u2019s and Maternity Education and Research Hospital, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuray Aktay","family":"Ayaz","sequence":"additional","affiliation":[{"name":"Pediatric Haematology\u2013Oncology Clinic, Bakirkoy Children\u2019s and Maternity Education and Research Hospital, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zafer","family":"Baslar","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Istanbul University, Cerrahpasa Medical School, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,2,12]]},"reference":[{"key":"bibr1-1076029611435091","doi-asserted-by":"publisher","DOI":"10.1172\/JCI102477"},{"key":"bibr2-1076029611435091","first-page":"1887","volume-title":"Williams Hematology","volume":"116","author":"Lichtman MA","year":"2006","edition":"7"},{"key":"bibr3-1076029611435091","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2004.00944.x"},{"key":"bibr4-1076029611435091","doi-asserted-by":"publisher","DOI":"10.1097\/00001721-200306001-00012"},{"key":"bibr5-1076029611435091","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2001.00100.x"},{"key":"bibr6-1076029611435091","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-02-0595"},{"issue":"5","key":"bibr7-1076029611435091","first-page":"901","volume":"94","author":"Giansily-Blaizot M","year":"2005","journal-title":"Thromb Haemost"},{"key":"bibr8-1076029611435091","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01751.x"},{"key":"bibr9-1076029611435091","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1225756"},{"key":"bibr10-1076029611435091","unstructured":"World Federation of Haemophilia.www.wfh.org. 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