{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:06:56Z","timestamp":1789171616938,"version":"build-2803163510"},"reference-count":67,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2013,5,7]],"date-time":"2013-05-07T00:00:00Z","timestamp":1367884800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:p>\n                    Aspirin (ASA) is recommended for the prevention of cardiovascular disease; however, the compliance is low. Reported use may not reflect actual use. Serum thromboxane B\n                    <jats:sub>2<\/jats:sub>\n                    (STxB\n                    <jats:sub>2<\/jats:sub>\n                    ) measurement was evaluated to validate reported ASA use. Males aged 45 to 79 years and females aged 55 to 79 years completed a survey and STxB\n                    <jats:sub>2<\/jats:sub>\n                    measurement (Thromboxane B\n                    <jats:sub>2<\/jats:sub>\n                    EIA Kit; Cayman Chemical, Ann Arbor, Michigan). The 107 patients were grouped by use of ASA (56 ASA+ and 51 ASA\u2212) and possible interfering medications (INT) such as nonsteroidal anti-inflammatory drugs. The STxB\n                    <jats:sub>2<\/jats:sub>\n                    levels (ng\/mL) were significantly lower in ASA users: ASA+ INT\u2212 3.0 (0.7, 8.4), ASA+ INT+ 2.0 (0.8, 4.9), ASA\u2212 INT+ 176 (75, 390), and ASA\u2212 INT\u2212 271 (199, 366). The INT use did not cause a significant difference in STxB\n                    <jats:sub>2<\/jats:sub>\n                    levels. A STxB\n                    <jats:sub>2<\/jats:sub>\n                    cut point of 25 ng\/mL had high sensitivity (94.1%) and specificity (91.1%) for ASA use. The STxB\n                    <jats:sub>2<\/jats:sub>\n                    was a reliable marker of ASA use and could be used to confirm ASA exposure in population-based health studies.\n                  <\/jats:p>","DOI":"10.1177\/1076029613486537","type":"journal-article","created":{"date-parts":[[2013,5,8]],"date-time":"2013-05-08T00:07:38Z","timestamp":1367971658000},"page":"385-392","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Confirmation of Reported Aspirin Use in Community Studies"],"prefix":"10.1177","volume":"20","author":[{"given":"Nicole Dodge","family":"Zantek","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell V.","family":"Luepker","sequence":"additional","affiliation":[{"name":"Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue","family":"Duval","sequence":"additional","affiliation":[{"name":"Lillehei Clinical Research Unit, University of Minnesota Medical School, Minneapolis, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Miller","sequence":"additional","affiliation":[{"name":"Lillehei Heart Institute and Cardiovascular Division, Medical School, University of Minnesota, Minneapolis, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niki","family":"Oldenburg","sequence":"additional","affiliation":[{"name":"Lillehei Heart Institute and Cardiovascular Division, Medical School, University of Minnesota, Minneapolis, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan T.","family":"Hirsch","sequence":"additional","affiliation":[{"name":"Lillehei Heart Institute and Cardiovascular Division, Medical School, University of Minnesota, Minneapolis, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,5,7]]},"reference":[{"key":"bibr1-1076029613486537","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.324.7329.71"},{"key":"bibr2-1076029613486537","doi-asserted-by":"publisher","DOI":"10.1378\/chest.119.1_suppl.39S"},{"key":"bibr3-1076029613486537","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.162.19.2197"},{"key":"bibr4-1076029613486537","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-6-200903170-00008"},{"key":"bibr5-1076029613486537","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0b013e3181f7d043"},{"key":"bibr6-1076029613486537","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0b013e3181fcb238"},{"issue":"8","key":"bibr7-1076029613486537","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/j.jacc.2010.11.005","volume":"57","author":"Brott TG","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"bibr8-1076029613486537","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-2306"},{"key":"bibr9-1076029613486537","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2011.2990"},{"key":"bibr10-1076029613486537","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-124-3-199602010-00002"},{"key":"bibr11-1076029613486537","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(96)90173-8"},{"key":"bibr12-1076029613486537","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.10.1097"},{"key":"bibr13-1076029613486537","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2009.08.029"},{"key":"bibr14-1076029613486537","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2004.03.008"},{"key":"bibr15-1076029613486537","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.2.197"},{"key":"bibr16-1076029613486537","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0020353"},{"key":"bibr17-1076029613486537","unstructured":"New public-private sector initiative aims to prevent 1 million heart attacks and strokes in five years [press release]. Washington, DC: HHS News, U.S. Department of Health and Human Services. http:\/\/www.hhs.gov\/news\/press\/2011pres\/09\/20110913a.html.Accessed September 13, 2011."},{"key":"bibr18-1076029613486537","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1110421"},{"key":"bibr19-1076029613486537","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2009.02.013"},{"key":"bibr20-1076029613486537","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-6-46"},{"key":"bibr21-1076029613486537","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2003.07.011"},{"key":"bibr22-1076029613486537","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108132"},{"key":"bibr23-1076029613486537","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108941"},{"key":"bibr24-1076029613486537","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.5.9.1907252"},{"key":"bibr25-1076029613486537","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.72.6.1177"},{"key":"bibr26-1076029613486537","doi-asserted-by":"publisher","DOI":"10.1038\/nsb0895-637"},{"key":"bibr27-1076029613486537","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110576"},{"key":"bibr28-1076029613486537","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.4.1109"},{"key":"bibr29-1076029613486537","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110814"},{"key":"bibr30-1076029613486537","doi-asserted-by":"publisher","DOI":"10.1007\/BF02265118"},{"key":"bibr31-1076029613486537","doi-asserted-by":"publisher","DOI":"10.1016\/S0223-5234(01)01197-7"},{"key":"bibr32-1076029613486537","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)53294-4"},{"key":"bibr33-1076029613486537","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.24.11693"},{"key":"bibr34-1076029613486537","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.3.4.383"},{"key":"bibr35-1076029613486537","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa003199"},{"key":"bibr36-1076029613486537","doi-asserted-by":"publisher","DOI":"10.1016\/0090-6980(82)90123-X"},{"key":"bibr37-1076029613486537","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.01.045"},{"key":"bibr38-1076029613486537","doi-asserted-by":"publisher","DOI":"10.1021\/bi952776w"},{"key":"bibr39-1076029613486537","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111110"},{"key":"bibr40-1076029613486537","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.72.8.2994"},{"key":"bibr41-1076029613486537","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199006213222503"},{"key":"bibr42-1076029613486537","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2010.03.013"},{"key":"bibr43-1076029613486537","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(96)00017-5"},{"key":"bibr44-1076029613486537","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.86.5.1495"},{"key":"bibr45-1076029613486537","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.83.5.1698"},{"key":"bibr46-1076029613486537","unstructured":"Thromboxane B\n                      2\n                      EIA Kit [package insert]. Ann Arbor, MI: Cayman Chemical Company; 2012."},{"key":"bibr47-1076029613486537","doi-asserted-by":"publisher","DOI":"10.1177\/107602960100700111"},{"key":"bibr48-1076029613486537","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01289-X"},{"key":"bibr49-1076029613486537","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.23.10.1400"},{"key":"bibr50-1076029613486537","doi-asserted-by":"publisher","DOI":"10.1160\/TH09-07-0470"},{"key":"bibr51-1076029613486537","doi-asserted-by":"publisher","DOI":"10.1592\/phco.23.5.579.32206"},{"key":"bibr52-1076029613486537","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2011.10.009"},{"key":"bibr53-1076029613486537","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2009.00243.x"},{"key":"bibr54-1076029613486537","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2010.02299.x"},{"key":"bibr55-1076029613486537","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2010.481249"},{"key":"bibr56-1076029613486537","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2005.01.011"},{"key":"bibr57-1076029613486537","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2008.12.034"},{"key":"bibr58-1076029613486537","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.596627"},{"key":"bibr59-1076029613486537","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000231683.43347.ec"},{"key":"bibr60-1076029613486537","doi-asserted-by":"publisher","DOI":"10.1160\/TH09-08-0527"},{"key":"bibr61-1076029613486537","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39430.529549.BE"},{"key":"bibr62-1076029613486537","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2007.12.010"},{"key":"bibr63-1076029613486537","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm226"},{"key":"bibr64-1076029613486537","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.675587"},{"issue":"2","key":"bibr65-1076029613486537","first-page":"404","volume":"102","author":"Blais N","year":"2009","journal-title":"Thromb Haemost"},{"key":"bibr66-1076029613486537","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.10.047"},{"key":"bibr67-1076029613486537","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn562"}],"container-title":["Clinical and Applied Thrombosis\/Hemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1076029613486537","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1076029613486537","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1076029613486537","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:05:00Z","timestamp":1777385100000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1076029613486537"}},"subtitle":["Utility of Serum Thromboxane B\n                    <sub>2<\/sub>\n                    Measurement"],"short-title":[],"issued":{"date-parts":[[2013,5,7]]},"references-count":67,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["10.1177\/1076029613486537"],"URL":"https:\/\/doi.org\/10.1177\/1076029613486537","relation":{},"ISSN":["1076-0296","1938-2723"],"issn-type":[{"value":"1076-0296","type":"print"},{"value":"1938-2723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,7]]}}}