{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:13:00Z","timestamp":1777479180757,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2013,6,6]],"date-time":"2013-06-06T00:00:00Z","timestamp":1370476800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:p>We assessed the prevalence of elevated quantitative latex agglutination assay for D-dimer in patients in the emergency department in whom pulmonary embolism (PE) was excluded. D-dimer was normal (&lt;230 ng\/mL) in 435 (83%) of the 522 patients. D-dimer was normal in 88% of the patients with musculoskeletal or related chest pain, 74% with pleurisy or pleuritic chest pain, and 85% with upper respiratory tract infection. D-dimer was 230 to 500 ng\/mL in 65 (75%) of the 87 in whom D-dimer was elevated. Clinical probability was low in 31 (48%) of the 65 patients with D-dimer levels of 230 to 500 ng\/mL. D-dimer was 230 to 500 ng\/mL and clinical probability was low in 31 (36%) of the 87 patients who had computed tomographic (CT) angiograms because of elevated D-dimer. Negative likelihood ratio for PE is sufficiently low that PE can be excluded with reasonable certainty in such patients. Tailoring cutoff value to 500 ng\/mL in patients with low clinical probability would have reduced CT angiograms by 36%.<\/jats:p>","DOI":"10.1177\/1076029613491457","type":"journal-article","created":{"date-parts":[[2013,6,6]],"date-time":"2013-06-06T22:44:38Z","timestamp":1370558678000},"page":"807-812","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Specificity of Quantitative Latex Agglutination Assay for\n                    <scp>D<\/scp>\n                    -dimer in Exclusion of Pulmonary Embolism in the Emergency Department"],"prefix":"10.1177","volume":"20","author":[{"given":"Paul D.","family":"Stein","sequence":"first","affiliation":[{"name":"Department of Osteopathic Medical Specialties, Michigan State University College of Osteopathic Medicine, East Lansing, Michigan, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fadi","family":"Matta","sequence":"additional","affiliation":[{"name":"Department of Osteopathic Medical Specialties, Michigan State University College of Osteopathic Medicine, East Lansing, Michigan, MI, USA"},{"name":"Department of Research, St Mary Mercy Hospital, Livonia, Michigan, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel J.","family":"Sabra","sequence":"additional","affiliation":[{"name":"Department of Research, St Mary Mercy Hospital, Livonia, Michigan, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Tana","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, St Mary Mercy Hospital, Livonia, Michigan, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Gough","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, St Mary Mercy 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